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Gene/ORF F57F5.5 (pkc-1) Ace View of F57F5.5
F57F5.5 Details Help
Description  pkc-1 encodes a serine/threonine protein kinase that is orthologous to mammalian protein kinase C epsilon (PRKCE), a member of the nPKC subgroup of the protein kinase C superfamily; together with UNC-13, PKC-1 may act downstream of goa-1 to modulate phorbol ester-induced stimulation of acetylcholine release at NMJs; PKC-1 positively regulates locomotion, and affects thermotaxis and chemotaxis together with kin-11; PKC-1 is required for regulating several behaviors including sensation of volatile and soluble compounds, osmolarity, and temperature (thermosensation); PKC-1 is also required for phorbolester-induced stimulation of acetylcholine release at neuromuscular junctions; PKC-1 localizes to the processes and cell bodies of approximately 75 sensory neurons and interneurons, and pkc-1 mRNA is detectable at varying levels during larval and adult stages.
Homology Group (KOG)  Serine/threonine protein kinase
GO Terms  neurotransmitter secretion (GO:0007269) ; chemotaxis (GO:0006935) ; positive regulation of locomotion (GO:0040017) ; protein kinase C activity (GO:0004697) ; intracellular signaling cascade (GO:0007242) ; protein serine/threonine kinase activity (GO:0004674) ; ATP binding (GO:0005524) ; protein amino acid phosphorylation (GO:0006468) ; protein kinase activity (GO:0004672) ; protein-tyrosine kinase activity (GO:0004713)
Location   V:12016612..12027149
RNAi Phenotypes
Postembryonic aldicarb_resistant ; aldicarb_resistant ; aldicarb_resistant ; aldicarb_resistant ; aldicarb_resistant
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Wild Type RNAi Experiments
WBRNAi00060230 WT
WBRNAi00060224 WT
WBRNAi00060229 WT
JA:F57F5.5 WT
JA:F10C2.1 WT
Cenix:66-h6 WT
WBRNAi00060222 WT
Experiments with Non-Wild Phenotypes
WBRNAi00060227 aldicarb_resistant
WBRNAi00060228 aldicarb_resistant
WBRNAi00060223 aldicarb_resistant
WBRNAi00060225 aldicarb_resistant
WBRNAi00060226 aldicarb_resistant
Gene Plot of F57F5.5 Browse using GBrowse
Gene Map