Ace View of F57F5.5 | |||
F57F5.5 Details | |||
Description | pkc-1 encodes a serine/threonine protein kinase that is orthologous to mammalian protein kinase C epsilon (PRKCE), a member of the nPKC subgroup of the protein kinase C superfamily; together with UNC-13, PKC-1 may act downstream of goa-1 to modulate phorbol ester-induced stimulation of acetylcholine release at NMJs; PKC-1 positively regulates locomotion, and affects thermotaxis and chemotaxis together with kin-11; PKC-1 is required for regulating several behaviors including sensation of volatile and soluble compounds, osmolarity, and temperature (thermosensation); PKC-1 is also required for phorbolester-induced stimulation of acetylcholine release at neuromuscular junctions; PKC-1 localizes to the processes and cell bodies of approximately 75 sensory neurons and interneurons, and pkc-1 mRNA is detectable at varying levels during larval and adult stages. | ||
Homology Group (KOG) | Serine/threonine protein kinase |
||
GO Terms | neurotransmitter secretion (GO:0007269) ; chemotaxis (GO:0006935) ; positive regulation of locomotion (GO:0040017) ; protein kinase C activity (GO:0004697) ; intracellular signaling cascade (GO:0007242) ; protein serine/threonine kinase activity (GO:0004674) ; ATP binding (GO:0005524) ; protein amino acid phosphorylation (GO:0006468) ; protein kinase activity (GO:0004672) ; protein-tyrosine kinase activity (GO:0004713) | ||
Location | V:12016612..12027149 | ||
RNAi Phenotypes |
|
||
External Links | |||
Associated RNAi Experiments | |||
Cenix:66-h6 | |||
Adult Phenotypes | WT |
||
RNAi Reagent Name & Type | Cenix:66-h6 (PCR reagent) | ||
Delivery Method | Injection | ||
Remark | 3/3 tests are wildtype. | ||
Laboratory | TH | ||
Date | 2005-3-24 | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
JA:F10C2.1 | |||
Adult Phenotypes | WT |
||
RNAi Reagent Name & Type | sjj_F10C2.1 (PCR reagent) | ||
Laboratory | JA | ||
Date | 2003-1-10 | ||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||
JA:F57F5.5 | |||
Adult Phenotypes | WT |
||
RNAi Reagent Name & Type | sjj_F57F5.5 (PCR reagent) | ||
Laboratory | JA | ||
Date | 2003-1-10 | ||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||
WBRNAi00060222 | |||
Adult Phenotypes | WT |
||
RNAi Reagent Name & Type | sjj_F57F5.5 (PCR reagent) | ||
Delivery Method | Bacterial_feeding | ||
Laboratory | KP | ||
Date | 2005-5-09 | ||
Reference | Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...." | ||
WBRNAi00060223 | |||
Adult Phenotypes | aldicarb_resistant
Animals displayed resistance to paralysis on aldicarb in 6 out of 8 trials. |
||
RNAi Reagent Name & Type | sjj_F57F5.5 (PCR reagent) | ||
Delivery Method | Bacterial_feeding | ||
Laboratory | KP | ||
Date | 2005-5-09 | ||
Reference | Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...." | ||
WBRNAi00060224 | |||
Adult Phenotypes | WT |
||
RNAi Reagent Name & Type | sjj_F57F5.5 (PCR reagent) | ||
Delivery Method | Bacterial_feeding | ||
Laboratory | KP | ||
Date | 2005-5-09 | ||
Reference | Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...." | ||
WBRNAi00060225 | |||
Adult Phenotypes | aldicarb_resistant
Animals displayed resistance to paralysis on aldicarb in 2 out of 4 trials. |
||
RNAi Reagent Name & Type | sjj_F57F5.5 (PCR reagent) | ||
Delivery Method | Bacterial_feeding | ||
Laboratory | KP | ||
Date | 2005-5-09 | ||
Reference | Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...." | ||
WBRNAi00060226 | |||
Adult Phenotypes | aldicarb_resistant
Animals displayed resistance to paralysis on aldicarb in 3 out of 4 trials. |
||
RNAi Reagent Name & Type | sjj_F57F5.5 (PCR reagent) | ||
Delivery Method | Bacterial_feeding | ||
Laboratory | KP | ||
Date | 2005-5-09 | ||
Reference | Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...." | ||
WBRNAi00060227 | |||
Adult Phenotypes | aldicarb_resistant
Animals displayed resistance to paralysis on aldicarb in 4 out of 4 trials. |
||
RNAi Reagent Name & Type | sjj_F57F5.5 (PCR reagent) | ||
Delivery Method | Bacterial_feeding | ||
Laboratory | KP | ||
Date | 2005-5-09 | ||
Reference | Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...." | ||
WBRNAi00060228 | |||
Adult Phenotypes | aldicarb_resistant
Animals displayed resistance to paralysis on aldicarb in 4 out of 4 trials. |
||
RNAi Reagent Name & Type | sjj_F57F5.5 (PCR reagent) | ||
Delivery Method | Bacterial_feeding | ||
Laboratory | KP | ||
Date | 2005-5-09 | ||
Reference | Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...." | ||
WBRNAi00060229 | |||
Adult Phenotypes | WT |
||
RNAi Reagent Name & Type | sjj_F57F5.5 (PCR reagent) | ||
Delivery Method | Bacterial_feeding | ||
Laboratory | KP | ||
Date | 2005-5-09 | ||
Reference | Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...." | ||
WBRNAi00060230 | |||
Adult Phenotypes | WT |
||
RNAi Reagent Name & Type | sjj_F57F5.5 (PCR reagent) | ||
Delivery Method | Bacterial_feeding | ||
Laboratory | KP | ||
Date | 2005-5-09 | ||
Reference | Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...." | ||
Gene Plot of F57F5.5 | |||