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Gene/ORF F57F5.5 (pkc-1) Ace View of F57F5.5
F57F5.5 Details Help
Description  pkc-1 encodes a serine/threonine protein kinase that is orthologous to mammalian protein kinase C epsilon (PRKCE), a member of the nPKC subgroup of the protein kinase C superfamily; together with UNC-13, PKC-1 may act downstream of goa-1 to modulate phorbol ester-induced stimulation of acetylcholine release at NMJs; PKC-1 positively regulates locomotion, and affects thermotaxis and chemotaxis together with kin-11; PKC-1 is required for regulating several behaviors including sensation of volatile and soluble compounds, osmolarity, and temperature (thermosensation); PKC-1 is also required for phorbolester-induced stimulation of acetylcholine release at neuromuscular junctions; PKC-1 localizes to the processes and cell bodies of approximately 75 sensory neurons and interneurons, and pkc-1 mRNA is detectable at varying levels during larval and adult stages.
Homology Group (KOG)  Serine/threonine protein kinase
GO Terms  neurotransmitter secretion (GO:0007269) ; chemotaxis (GO:0006935) ; positive regulation of locomotion (GO:0040017) ; protein kinase C activity (GO:0004697) ; intracellular signaling cascade (GO:0007242) ; protein serine/threonine kinase activity (GO:0004674) ; ATP binding (GO:0005524) ; protein amino acid phosphorylation (GO:0006468) ; protein kinase activity (GO:0004672) ; protein-tyrosine kinase activity (GO:0004713)
Location   V:12016612..12027149
RNAi Phenotypes
Postembryonic aldicarb_resistant ; aldicarb_resistant ; aldicarb_resistant ; aldicarb_resistant ; aldicarb_resistant
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:66-h6
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:66-h6 (PCR reagent)
Delivery Method  Injection
Remark  3/3 tests are wildtype.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:F10C2.1
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_F10C2.1 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
JA:F57F5.5
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_F57F5.5 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
WBRNAi00060222
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_F57F5.5 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  KP
Date  2005-5-09
Reference  Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...."
WBRNAi00060223
Adult Phenotypes  aldicarb_resistant Animals displayed resistance to paralysis on aldicarb in 6 out of 8 trials.
RNAi Reagent Name & Type sjj_F57F5.5 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  KP
Date  2005-5-09
Reference  Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...."
WBRNAi00060224
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_F57F5.5 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  KP
Date  2005-5-09
Reference  Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...."
WBRNAi00060225
Adult Phenotypes  aldicarb_resistant Animals displayed resistance to paralysis on aldicarb in 2 out of 4 trials.
RNAi Reagent Name & Type sjj_F57F5.5 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  KP
Date  2005-5-09
Reference  Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...."
WBRNAi00060226
Adult Phenotypes  aldicarb_resistant Animals displayed resistance to paralysis on aldicarb in 3 out of 4 trials.
RNAi Reagent Name & Type sjj_F57F5.5 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  KP
Date  2005-5-09
Reference  Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...."
WBRNAi00060227
Adult Phenotypes  aldicarb_resistant Animals displayed resistance to paralysis on aldicarb in 4 out of 4 trials.
RNAi Reagent Name & Type sjj_F57F5.5 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  KP
Date  2005-5-09
Reference  Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...."
WBRNAi00060228
Adult Phenotypes  aldicarb_resistant Animals displayed resistance to paralysis on aldicarb in 4 out of 4 trials.
RNAi Reagent Name & Type sjj_F57F5.5 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  KP
Date  2005-5-09
Reference  Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...."
WBRNAi00060229
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_F57F5.5 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  KP
Date  2005-5-09
Reference  Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...."
WBRNAi00060230
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_F57F5.5 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  KP
Date  2005-5-09
Reference  Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...."
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