Ace View of F58A4.3 | |||||
F58A4.3 Details | |||||
Description | The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos. | ||||
Homology Group (KOG) | Histones H3 and H4 |
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GO Terms | mitotic chromosome segregation (GO:0000070) ; centromere/kinetochore complex maturation (GO:0000069) ; mitotic spindle assembly (GO:0007052) ; condensed chromosome, pericentric region (GO:0000779) ; nucleus (GO:0005634) ; protein binding (GO:0005515) ; DNA binding (GO:0003677) ; nucleosome assembly (GO:0006334) ; chromosome organization and biogenesis (sensu Eukarya) (GO:0007001) ; nucleosome (GO:0000786) | ||||
Location | III:9614802..9616762 | ||||
RNAi Phenotypes |
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External Links | |||||
Associated RNAi Experiments | |||||
Experiments with Non-Wild Phenotypes | |||||
Simmer:F58A4.3 | Emb | ||||
Cenix:335-f3 | Emb ; Sister Chromatid Separation abnormal (Cross-eyed) | ||||
Cenix:175-b7 | Emb ; Sister Chromatid Separation abnormal (Cross-eyed) | ||||
JA:F58A4.3 | Emb ; Ste | ||||
TH:335f3 | Emb | ||||
Gene Plot of F58A4.3 | |||||