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Gene/ORF F58A4.3 (hcp-3) Ace View of F58A4.3
F58A4.3 Details Help
Description  The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos.
Homology Group (KOG)  Histones H3 and H4
GO Terms  mitotic chromosome segregation (GO:0000070) ; centromere/kinetochore complex maturation (GO:0000069) ; mitotic spindle assembly (GO:0007052) ; condensed chromosome, pericentric region (GO:0000779) ; nucleus (GO:0005634) ; protein binding (GO:0005515) ; DNA binding (GO:0003677) ; nucleosome assembly (GO:0006334) ; chromosome organization and biogenesis (sensu Eukarya) (GO:0007001) ; nucleosome (GO:0000786)
Location   III:9614802..9616762
RNAi Phenotypes
Early_embryo Sister Chromatid Separation abnormal (Cross-eyed) ; Sister Chromatid Separation abnormal (Cross-eyed) ; Chromosome Segregation (karyomeres) abnormal
Adult Pvl ; Rup ; Ste
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Experiments with Non-Wild Phenotypes
Simmer:F58A4.3 Emb
Cenix:335-f3 Emb ; Sister Chromatid Separation abnormal (Cross-eyed)
Cenix:175-b7 Emb ; Sister Chromatid Separation abnormal (Cross-eyed)
JA:F58A4.3 Emb ; Ste
TH:335f3 Emb
Gene Plot of F58A4.3 Browse using GBrowse
Gene Map