Ace View of F58B6.3 | |||||
F58B6.3 Details | |||||
Description | par-2 encodes a protein containing a C3HC4-type RING-finger, a specialized type of zinc-finger found in E3 ubiquitin ligase subunits; PAR-2 is required maternally for polarization of the C. elegans zygote along the anterior-posterior (A-P) axis and is asymmetrically localized to the posterior cortex of the one- and two-cell embryo via interdependent interactions with PAR-3, PAR-6, and PKC-3. | ||||
GO Terms | asymmetric protein localization involved in cell fate commitment (GO:0045167) ; asymmetric cytokinesis (GO:0008356) ; mitotic spindle orientation (GO:0000132) ; cell cortex (GO:0005938) ; zinc ion binding (GO:0008270) ; ATP binding (GO:0005524) ; ubiquitin-protein ligase activity (GO:0004842) ; protein ubiquitination (GO:0016567) ; ubiquitin ligase complex (GO:0000151) | ||||
Location | III:1080992..1095435 | ||||
RNAi Phenotypes |
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External Links | |||||
Associated RNAi Experiments | |||||
Cenix:238-a3 | |||||
Embryonic Phenotypes | Emb Penetrance None reported | ||||
Adult Phenotypes | Asymmetry of Division abnormal |
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RNAi Reagent Name & Type | Cenix:238-a3 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Remark | early embryonic: Asymmetry of Division | ||||
Laboratory | TH | ||||
Date | 2005-3-24 | ||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||
JA:F58B6.3 | |||||
Embryonic Phenotypes | Emb Penetrance 100 % | ||||
Adult Phenotypes | Muv Pvl Rup |
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RNAi Reagent Name & Type | sjj_F58B6.3 (PCR reagent) | ||||
Laboratory | JA | ||||
Date | 2003-1-10 | ||||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||||
Simmer:F58B6.3 | |||||
Embryonic Phenotypes | Emb Penetrance 90 % | ||||
RNAi Reagent Name & Type | sjj_F58B6.3 (PCR reagent) | ||||
Laboratory | NL | ||||
Date | 2003-10-01 | ||||
Strain | NL4256 rrf-3(pk1426) | ||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||
Gene Plot of F58B6.3 | |||||