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Gene/ORF F58H12.1 (kin-29) Ace View of F58H12.1
F58H12.1 Details Help
Description  kin-29 encodes a serine/threonine kinase with significant homology in the kinase domain to the AMP-activated protein kinase (AMPK) and SNF1 kinases; the AMP-kinase cascade is activated by cellular stresses that deplete ATP; AMP-kinase is believed to protect the mammalian cell by 'switching off' ATP-consuming pathways like fatty acid synthesis, by phosphorylating key regulatory enzymes, and switching on alternative pathways for ATP generation; kin-29 is involved in regulating the expression of chemosensory receptors and entry into the daur pathway; kin-29 also affects body size via interaction with the Sma/Mab pathway and lifespan, with mutants exhibiting a smaller body size and increased life span; a functional KIN-29-GFP fusion protein is expressed in sensory neurons and many other cell types, and localizes to the cytoplasm; under conditions of cellular stress like heat shock and starvation, KIN-29-GFP translocates to the nucleus.
Homology Group (KOG)  Serine/threonine protein kinase
GO Terms  detection of chemical stimulus during sensory perception (GO:0050907) ; response to stress (GO:0006950) ; negative regulation of fatty acid biosynthesis (GO:0045717) ; protein amino acid phosphorylation (GO:0006468) ; regulation of body size (GO:0040014) ; dauer entry (GO:0043053) ; cytoplasm (GO:0005737) ; nucleus (GO:0005634) ; protein serine/threonine kinase activity (GO:0004674) ; protein kinase activity (GO:0004672) ; ATP binding (GO:0005524)
Location   X:2843524..2852872
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:105-c3
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:105-c3 (PCR reagent)
Delivery Method  Injection
Remark  3/3 tests are wildtype
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:F58H12.1
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_F58H12.1 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
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