Ace View of F58H12.1 | |
F58H12.1 Details | |
Description | kin-29 encodes a serine/threonine kinase with significant homology in the kinase domain to the AMP-activated protein kinase (AMPK) and SNF1 kinases; the AMP-kinase cascade is activated by cellular stresses that deplete ATP; AMP-kinase is believed to protect the mammalian cell by 'switching off' ATP-consuming pathways like fatty acid synthesis, by phosphorylating key regulatory enzymes, and switching on alternative pathways for ATP generation; kin-29 is involved in regulating the expression of chemosensory receptors and entry into the daur pathway; kin-29 also affects body size via interaction with the Sma/Mab pathway and lifespan, with mutants exhibiting a smaller body size and increased life span; a functional KIN-29-GFP fusion protein is expressed in sensory neurons and many other cell types, and localizes to the cytoplasm; under conditions of cellular stress like heat shock and starvation, KIN-29-GFP translocates to the nucleus. |
Homology Group (KOG) | Serine/threonine protein kinase |
GO Terms | detection of chemical stimulus during sensory perception (GO:0050907) ; response to stress (GO:0006950) ; negative regulation of fatty acid biosynthesis (GO:0045717) ; protein amino acid phosphorylation (GO:0006468) ; regulation of body size (GO:0040014) ; dauer entry (GO:0043053) ; cytoplasm (GO:0005737) ; nucleus (GO:0005634) ; protein serine/threonine kinase activity (GO:0004674) ; protein kinase activity (GO:0004672) ; ATP binding (GO:0005524) |
Location | X:2843524..2852872 |
RNAi Phenotypes | No phenotypes observed. |
External Links | |
Associated RNAi Experiments | |
Cenix:105-c3 | |
Adult Phenotypes | WT |
RNAi Reagent Name & Type | Cenix:105-c3 (PCR reagent) |
Delivery Method | Injection |
Remark | 3/3 tests are wildtype |
Laboratory | TH |
Date | 2005-3-24 |
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
JA:F58H12.1 | |
Adult Phenotypes | WT |
RNAi Reagent Name & Type | sjj_F58H12.1 (PCR reagent) |
Laboratory | JA |
Date | 2003-1-10 |
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." |
Gene Plot of F58H12.1 | |