| Ace View of F59E12.2 | |||||
| F59E12.2 Details | |||||
| Description | zyg-1 encodes a homolog of polo-like and calcium-dependent kinases that is required for daughter centriole formation; ZYG-1 localizes transiently to centrosomes and acts at least one cell cycle prior to each spindle assembly event; ZYG-1 activity is required for proper localization of the SAS-5 and SAS-6 coiled-coil proteins that are also required for centriole duplication. | ||||
| Homology Group (KOG) | Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily |
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| GO Terms | cell division (GO:0051301) ; reproduction (GO:0000003) ; centriole replication (GO:0007099) ; mitotic spindle assembly (GO:0051227) ; embryonic development (sensu Animalia) (GO:0009792) ; protein localization (GO:0008104) ; centrosome (GO:0005813) ; protein kinase activity (GO:0004672) ; ATP binding (GO:0005524) ; protein amino acid phosphorylation (GO:0006468) ; protein-tyrosine kinase activity (GO:0004713) | ||||
| Location | II:5649318..5654792 | ||||
| RNAi Phenotypes |
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| External Links |    |
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| Associated RNAi Experiments | |||||
| Cenix:148-e8 | |||||
| Embryonic Phenotypes | Emb Penetrance None reported | ||||
| Adult Phenotypes | Spindle Assembly abnormal |
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| RNAi Reagent Name & Type | Cenix:148-e8 (PCR reagent) | ||||
| Delivery Method | Injection | ||||
| Remark | early embryonic: Spindle Assembly | ||||
| Laboratory | TH | ||||
| Date | 2005-3-24 | ||||
| Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||
| JA:F59E12.2 | |||||
| Embryonic Phenotypes | Emb Penetrance 40 % | ||||
| RNAi Reagent Name & Type | sjj_F59E12.2 (PCR reagent) | ||||
| Laboratory | JA | ||||
| Date | 2003-1-10 | ||||
| Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||||
| [cgc4699]:zyg-1 | |||||
| Embryonic Phenotypes | Emb Penetrance None reported | ||||
| Adult Phenotypes | Stp
resulted from partial RNAi effect Unc resulted from partial RNAi effect |
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| RNAi Reagent Name & Type | [cgc4699]:zyg-1 (PCR reagent) | ||||
| Delivery Method | Injection | ||||
| Laboratory | OC | ||||
| Date | 2001-5-18 | ||||
| Reference | O'Connell KF et al. (2001) Cell "The C. elegans zyg-1 gene encodes a regulator of centrosome duplication with ...." | ||||
| Gene Plot of F59E12.2 | |||||
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