Ace View of K01G5.7 | |||||
K01G5.7 Details | |||||
Description | This gene encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-1 is redundant for embryonic viability, due to its paralog TBB-2. | ||||
Homology Group (KOG) | Beta tubulin |
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GO Terms | structural molecule activity (GO:0005198) ; microtubule-based movement (GO:0007018) ; microtubule (GO:0005874) ; GTP binding (GO:0005525) ; cytoplasm (GO:0005737) ; GTPase activity (GO:0003924) ; protein polymerization (GO:0051258) ; protein complex (GO:0043234) | ||||
Location | III:10740351..10742727 | ||||
RNAi Phenotypes |
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External Links | |||||
Associated RNAi Experiments | |||||
Cenix:329-e9 | |||||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | Cenix:329-e9 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Remark | wild type | ||||
Laboratory | TH | ||||
Date | 2005-3-24 | ||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||
Cenix:320-e11 | |||||
Embryonic Phenotypes | Emb Penetrance None reported | ||||
Adult Phenotypes | Pnm |
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RNAi Reagent Name & Type | Cenix:320-e11 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Remark | early embryonic: Pronuclear Migration | ||||
Laboratory | TH | ||||
Date | 2005-3-24 | ||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||
Cenix:340-d5 | |||||
Embryonic Phenotypes | Emb Penetrance None reported | ||||
RNAi Reagent Name & Type | Cenix:340-d5 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Laboratory | TH | ||||
Date | 2005-3-24 | ||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||
Simmer:K01G5.7 | |||||
Embryonic Phenotypes | Emb Penetrance 100 % | ||||
RNAi Reagent Name & Type | sjj_K01G5.7 (PCR reagent) | ||||
Laboratory | NL | ||||
Date | 2003-10-01 | ||||
Strain | NL4256 rrf-3(pk1426) | ||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||
TH:320e11 | |||||
Embryonic Phenotypes | Emb Penetrance None reported | ||||
RNAi Reagent Name & Type | TH:320e11 (PCR reagent) | ||||
Remark | Phenotype comment -- Confirmed with independent dsRNA (K01G5.7-RNA2; similar phenotype). Phenotype could potentially be due to cross-RNAi inhibition of other tubulin genes (see BLASTN results). We note, however, that RNAi directed specifically against one other tubulin gene on chromosome III (C54C6.2; ben-1) failed to give rise to a phenotype, suggesting that the phenotype noted here may truly reflect a requirement for K01G5.7 function. | ||||
Laboratory | TH | ||||
Date | 2000-11-16 | ||||
Reference | Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." | ||||
TH:340d5 | |||||
Embryonic Phenotypes | Emb Penetrance None reported | ||||
RNAi Reagent Name & Type | TH:340d5 (PCR reagent) | ||||
Remark | Phenotype comment -- Confirmed with independent dsRNA (K01G5.7-RNA2; similar phenotype). Phenotype could potentially be due to cross-RNAi inhibition of other tubulin genes (see BLASTN results). We note, however, that RNAi directed specifically against one other tubulin gene on chromosome III (C54C6.2; ben-1) failed to give rise to a phenotype, suggesting that the phenotype noted here may truly reflect a requirement for K01G5.7 function. | ||||
Laboratory | TH | ||||
Date | 2000-11-16 | ||||
Reference | Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." | ||||
Gene Plot of K01G5.7 | |||||