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Gene/ORF K01G5.7 (tbb-1) Ace View of K01G5.7
K01G5.7 Details Help
Description  This gene encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-1 is redundant for embryonic viability, due to its paralog TBB-2.
Homology Group (KOG)  Beta tubulin
GO Terms  structural molecule activity (GO:0005198) ; microtubule-based movement (GO:0007018) ; microtubule (GO:0005874) ; GTP binding (GO:0005525) ; cytoplasm (GO:0005737) ; GTPase activity (GO:0003924) ; protein polymerization (GO:0051258) ; protein complex (GO:0043234)
Location   III:10740351..10742727
RNAi Phenotypes
Early_embryo Pnm
Larva Lva
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:329-e9
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:329-e9 (PCR reagent)
Delivery Method  Injection
Remark  wild type
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Cenix:320-e11
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  Pnm
RNAi Reagent Name & Type Cenix:320-e11 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Pronuclear Migration
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Cenix:340-d5
Embryonic Phenotypes  Emb Penetrance None reported
RNAi Reagent Name & Type Cenix:340-d5 (PCR reagent)
Delivery Method  Injection
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Simmer:K01G5.7
Embryonic Phenotypes  Emb Penetrance 100 %
RNAi Reagent Name & Type sjj_K01G5.7 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
TH:320e11
Embryonic Phenotypes  Emb Penetrance None reported
RNAi Reagent Name & Type TH:320e11 (PCR reagent)
Remark  Phenotype comment -- Confirmed with independent dsRNA (K01G5.7-RNA2; similar phenotype). Phenotype could potentially be due to cross-RNAi inhibition of other tubulin genes (see BLASTN results). We note, however, that RNAi directed specifically against one other tubulin gene on chromosome III (C54C6.2; ben-1) failed to give rise to a phenotype, suggesting that the phenotype noted here may truly reflect a requirement for K01G5.7 function.
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
TH:340d5
Embryonic Phenotypes  Emb Penetrance None reported
RNAi Reagent Name & Type TH:340d5 (PCR reagent)
Remark  Phenotype comment -- Confirmed with independent dsRNA (K01G5.7-RNA2; similar phenotype). Phenotype could potentially be due to cross-RNAi inhibition of other tubulin genes (see BLASTN results). We note, however, that RNAi directed specifically against one other tubulin gene on chromosome III (C54C6.2; ben-1) failed to give rise to a phenotype, suggesting that the phenotype noted here may truly reflect a requirement for K01G5.7 function.
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
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