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Gene/ORF K04G2.8 (apr-1) Ace View of K04G2.8
K04G2.8 Details Help
Description  The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39.
Homology Group (KOG)  Beta-catenin-binding protein APC, contains ARM repeats
GO Terms  beta-catenin binding (GO:0008013) ; binding (GO:0005488)
Location   I:8049636..8056182
RNAi Phenotypes
Postembryonic WT_postembryonic_morphology
Larva Lva ; Lva ; Lva ; Lvl ; Lvl ; Lvl
Adult Bmd ; Bmd ; Muv ; Muv ; Muv ; Unc ; Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Experiments with Non-Wild Phenotypes
JA:K04G2.8 Bmd ; Lvl ; Unc
Cenix:72-g4 Emb ; WT_postembryonic_morphology
Simmer:K04G2.8:Screen_A Bmd ; Emb ; Lva ; Lvl
Simmer:K04G2.8:Screen_B Emb ; Lvl
Gene Plot of K04G2.8 Browse using GBrowse
Gene Map