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Gene/ORF K04G2.8 (apr-1) Ace View of K04G2.8
K04G2.8 Details Help
Description  The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39.
Homology Group (KOG)  Beta-catenin-binding protein APC, contains ARM repeats
GO Terms  beta-catenin binding (GO:0008013) ; binding (GO:0005488)
Location   I:8049636..8056182
RNAi Phenotypes
Postembryonic WT_postembryonic_morphology
Larva Lva ; Lva ; Lva ; Lvl ; Lvl ; Lvl
Adult Bmd ; Bmd ; Muv ; Muv ; Muv ; Unc ; Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
JA:K04G2.8
Larval Phenotypes  Lvl
Adult Phenotypes  Bmd
Unc
RNAi Reagent Name & Type sjj_K04G2.8 (PCR reagent)
Laboratory  JA
Date  2000-11-16
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
Simmer:K04G2.8:Screen_A
Embryonic Phenotypes  Emb Penetrance 100 %
Larval Phenotypes  Lva
Lvl
Adult Phenotypes  Bmd
RNAi Reagent Name & Type sjj_K04G2.8 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:K04G2.8:Screen_B
Embryonic Phenotypes  Emb Penetrance 90 %
Larval Phenotypes  Lvl
RNAi Reagent Name & Type sjj_K04G2.8 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Cenix:72-g4
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  WT_postembryonic_morphology
RNAi Reagent Name & Type Cenix:72-g4 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: No significant defects.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Gene Plot of K04G2.8 Browse using GBrowse
Gene Map