Ace View of K04G2.8 | |||||||
K04G2.8 Details | |||||||
Description | The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39. | ||||||
Homology Group (KOG) | Beta-catenin-binding protein APC, contains ARM repeats |
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GO Terms | beta-catenin binding (GO:0008013) ; binding (GO:0005488) | ||||||
Location | I:8049636..8056182 | ||||||
RNAi Phenotypes |
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External Links | |||||||
Associated RNAi Experiments | |||||||
JA:K04G2.8 | |||||||
Larval Phenotypes | Lvl |
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Adult Phenotypes | Bmd Unc |
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RNAi Reagent Name & Type | sjj_K04G2.8 (PCR reagent) | ||||||
Laboratory | JA | ||||||
Date | 2000-11-16 | ||||||
Reference | Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...." | ||||||
Simmer:K04G2.8:Screen_A | |||||||
Embryonic Phenotypes | Emb Penetrance 100 % | ||||||
Larval Phenotypes | Lva Lvl |
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Adult Phenotypes | Bmd |
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RNAi Reagent Name & Type | sjj_K04G2.8 (PCR reagent) | ||||||
Laboratory | NL | ||||||
Date | 2003-10-01 | ||||||
Strain | NL4256 rrf-3(pk1426) | ||||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||||
Simmer:K04G2.8:Screen_B | |||||||
Embryonic Phenotypes | Emb Penetrance 90 % | ||||||
Larval Phenotypes | Lvl |
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RNAi Reagent Name & Type | sjj_K04G2.8 (PCR reagent) | ||||||
Laboratory | NL | ||||||
Date | 2003-10-01 | ||||||
Strain | NL4256 rrf-3(pk1426) | ||||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||||
Cenix:72-g4 | |||||||
Embryonic Phenotypes | Emb Penetrance None reported | ||||||
Adult Phenotypes | WT_postembryonic_morphology |
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RNAi Reagent Name & Type | Cenix:72-g4 (PCR reagent) | ||||||
Delivery Method | Injection | ||||||
Remark | early embryonic: No significant defects. | ||||||
Laboratory | TH | ||||||
Date | 2005-3-24 | ||||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||||
Gene Plot of K04G2.8 | |||||||