Ace View of M142.1 | |
M142.1 Details | |
Description | unc-119 encodes a novel protein that is highly conserved amongst metazoans; unc-119 activity is required for proper development of the nervous system, including axonal branching and fasciculation, and hence, for normal movement, chemosensation, and feeding; unc-119 is expressed pan-neuronally beginning in the early embryo (~60 cells) and continuing through adulthood; although the molecular function of UNC-119 is not yet known, human UNC119, which can rescue C. elegans unc-119 mutant animals, is reported to function as a receptor-associated activator of signal transduction; thus, UNC-119 may be part of a signal transduction pathway that mediates axonal patterning in response to external developmental cues. |
Homology Group (KOG) | Photoreceptor synaptic vesicle protein HRG4/UNC-119 |
GO Terms | locomotion (GO:0040011) ; chemosensory behavior (GO:0007635) ; feeding behavior (GO:0007631) ; negative regulation of axon extension (GO:0030517) ; axon (GO:0030424) ; molecular_function unknown (GO:0005554) |
Location | III:10905947..10909137 |
RNAi Phenotypes | No phenotypes observed. |
External Links | |
Associated RNAi Experiments | |
Cenix:324-a11 | |
Adult Phenotypes | WT |
RNAi Reagent Name & Type | Cenix:324-a11 (PCR reagent) |
Delivery Method | Injection |
Remark | wild type |
Laboratory | TH |
Date | 2005-3-24 |
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
JA:M142.1 | |
Adult Phenotypes | WT |
RNAi Reagent Name & Type | sjj_M142.1 (PCR reagent) |
Laboratory | JA |
Date | 2003-1-10 |
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." |
TH:324A11 | |
Adult Phenotypes | WTDIC phenotype -- Embryonic development normal |
RNAi Reagent Name & Type | TH:324A11 (PCR reagent) |
Delivery Method | Injection |
Laboratory | TH |
Date | 2000-11-16 |
Reference | Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." |
Gene Plot of M142.1 | |