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Gene/ORF M7.1 (let-70) Ace View of M7.1
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Description  let-70 encodes a class I E2 ubiquitin conjugating enzyme; let-70 was identified in screens for essential genes and phenotypic analyses indicate that loss of let-70 activity results in embryonic and larval lethality with defects in sarcomere assembly; purified LET-70 can stimulate the self-ubiquitylation activities of CHN-1 and UFD-2, E4 ubiquitin conjugation factors and, in addition, can stimulate the CHN-1- and UFD-2-dependent multiubiquitylation of UNC-45, a myosin-directed chaperone; in this manner, LET-70 may regulate UNC-45 degradation and myosin assembly; RNA blot analyses and a let-70-lacZ reporter fusion reveal that let-70 is abundantly expressed at all stages of development, including the dauer larval stage; strong staining is observed in most somatic tissues until adult stages, when expression generally becomes restricted to the nervous system.
Homology Group (KOG)  Ubiquitin-protein ligase
GO Terms  ubiquitin-like activating enzyme activity (GO:0008642) ; protein modification (GO:0006464) ; ubiquitin cycle (GO:0006512)
Location   IV:11080655..11082625
RNAi Phenotypes
Early_embryo Complex Phenotype
Postembryonic aldicarb_resistant ; Adl
Larva Let ; Let ; Lva
Adult Sck ; Pvl ; Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Wild Type RNAi Experiments
WBRNAi00060824 WT
Experiments with Non-Wild Phenotypes
WBRNAi00060823 aldicarb_resistant
WBRNAi00060826 Let
Cenix:186-e7 Complex Phenotype ; Emb
JA:M7.1 Adl ; Emb ; Pvl
Simmer:M7.1 Emb
WBRNAi00060825 Let
Gene Plot of M7.1 Browse using GBrowse
Gene Map