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Gene/ORF R05D11.3 (ran-4) Ace View of R05D11.3
R05D11.3 Details Help
Description  ran-4 encodes a ortholog of NUCLEAR TRANSPORT FACTOR 2 (NTF2) from S. cerevisiae and metazoa, which is predicted to interact with nucleoporins and to promote transport of RAN-1(+GDP) into the nucleus; RAN-4/NTF2 proteins are paralogous to the N-terminal domain of RasGAP SH3 binding proteins such as Drosophila RASPUTIN, and to delta-5-3-ketosteroid isomerases, while having no homology to Ran proteins per se; RAN-4 is essential for early embryogenesis; in mass RNAi assays, ran-4 is needed for embryonic viability, normally rapid growth, fertility, and normal pronuclear envelopes in the embryo.
Homology Group (KOG)  Nuclear transport factor 2
GO Terms  protein transporter activity (GO:0008565) ; protein-nucleus import (GO:0006606) ; intracellular (GO:0005622) ; nucleus (GO:0005634)
Location   I:8590804..8592362
RNAi Phenotypes
Early_embryo Pronuclear/Nuclear Appearance abnormal ; Pna
Larva Lva ; Lva ; Gro
Adult Unc ; Ste
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Wild Type RNAi Experiments
Cenix:149-f3 WT
Experiments with Non-Wild Phenotypes
Simmer:R05D11.3:Screen_B Emb ; Lva
JA:R05D11.3 Emb ; Gro ; Pna ; Ste
Cenix:125-h7 Emb ; Pronuclear/Nuclear Appearance abnormal
Simmer:R05D11.3:Screen_A Emb ; Lva ; Unc
Gene Plot of R05D11.3 Browse using GBrowse
Gene Map