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Gene/ORF R06C7.5 Ace View of R06C7.5
R06C7.5 Details Help
Description  The R06C7.5 gene encodes an ortholog of the human gene ADSL, which when mutated leads to adenylosuccinate lyase deficiency (OMIM:103050).
GO Terms  catalytic activity (GO:0003824) ; adenylosuccinate lyase activity (GO:0004018) ; purine ribonucleotide biosynthesis (GO:0009152)
Location   I:7246500..7249085
RNAi Phenotypes
Early_embryo Nmo
Postembryonic WT_postembryonic_morphology
Larva Gro ; Gro
Adult Bmd ; Egl ; Pvl ; Pvl ; Pvl ; Unc ; Unc ; Stp
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
JA:R06C7.5
Embryonic Phenotypes  Emb Penetrance 50 - 80 %
Adult Phenotypes  Bmd
Egl
Pvl
Adult Phenotypes  Nmo Differentiated, not enclosed
RNAi Reagent Name & Type sjj_R06C7.5 (PCR reagent)
Remark  granular cytoplasm
Laboratory  JA
Date  2000-11-16
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
Movies/Stacks/Images  /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif
Simmer:R06C7.5:Screen_A
Larval Phenotypes  Gro
Adult Phenotypes  Pvl
Unc
RNAi Reagent Name & Type sjj_R06C7.5 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:R06C7.5:Screen_B
Larval Phenotypes  Gro
Adult Phenotypes  Pvl
Stp
Unc
RNAi Reagent Name & Type sjj_R06C7.5 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Cenix:25-b7
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  WT_postembryonic_morphology
RNAi Reagent Name & Type Cenix:25-b7 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: No significant defects.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Gene Plot of R06C7.5 Browse using GBrowse
Gene Map