ORF Card Page

Gene/ORF R06F6.1 (cdl-1)

R06F6.1 Details

Description

cdl-1 encodes a homolog of human hairpin (stem-loop) binding proteins (HBP/SLBP) that bind to the hairpin (stem-loop) structure in the 3' untranslated region (3' UTR) of histone mRNAs, and thus promote histone pre-mRNA processing and translation of mature histone mRNA; CDL-1 is required for normally high levels of histone gene expression, normal cell division during late larval development, embryonic viability, normal vulval morphogenesis, normally rapid apoptosis, and fertility; CDL-1 binds to the stem-loop structure in the 3' UTR of core-histone mRNA; the cdl-1 promoter is most active in dividing cells during embryogenesis and postembryonic development; both CDL-1 and human HBP contain a minimal RNA-binding domain (RBD) of roughly 73 amino acids that has no similarity with other known RNA-binding motifs.

Homology Group (KOG)

Histone mRNA stem-loop binding protein

GO Terms

apoptosis (GO:0006915) ; embryonic development (GO:0009790) ; mitotic chromosome condensation (GO:0007076) ; nucleus (GO:0005634) ; cytoplasm (GO:0005737) ; mRNA 3' UTR binding (GO:0003730)

Location

II:10784963..10787580

RNAi Phenotypes

Early_embryo	Excessive blebbing ; EMS extends too far anteriorly ; Sister Chromatid Separation abnormal (Cross-eyed) ; Nuclei reform next to cell division remnant ; P0 spindle positioning defect ; Delayed P0 spindle rotation ; Ectopic cleavage furrows
Larva	Gro
Adult	Bmd ; Pvl ; Ste ; Rup

External Links

Associated RNAi Experiments

View Details

Experiments with Non-Wild Phenotypes

Simmer:R06F6.1

Emb

Cenix:200-b11

Emb ; Sister Chromatid Separation abnormal (Cross-eyed)

PF:GL1_8E5

Delayed P0 spindle rotation ; Ectopic cleavage furrows ; Emb ; EMS extends too far anteriorly ; Excessive blebbing ; Nuclei reform next to cell division remnant ; P0 spindle positioning defect

JA:R06F6.1

Bmd ; Emb ; Gro ; Rup

Gene Plot of R06F6.1

Browse using GBrowse