Ace View of R10E11.1 | |||
R10E11.1 Details | |||
Description | cbp-1 encodes a homolog of the mammalian transcriptional cofactors CBP (OMIM:600140) and p300 (E1A-BINDING PROTEIN, 300-KD; OMIM:602700) that have been shown to possess histone acetyltransferase activity, and which, when mutated, lead to Rubinstein-Taybi syndrome (OMIM:180849) and colorectal cancer (OMIM:114500); at least one splicing form of CBP-1 exhibits histone acetyltransferase (HAT) activity in vitro and has a glutamine/asparagine-rich domain; CBP-1 is required during embryogenesis for differentiation of all non-neuronal somatic cell types; CBP-1 is expressed very early in embryogenesis, suggesting that it may interact with maternally provided transcription factors, such as SKN-1, to specific developmental fates. | ||
Homology Group (KOG) | CREB binding protein/P300 and related TAZ Zn-finger proteins |
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GO Terms | embryonic development (GO:0009790) ; regulation of transcription (GO:0045449) ; spermatogenesis (GO:0007283) ; cytoplasm (GO:0005737) ; transcription cofactor activity (GO:0003712) ; histone acetyltransferase activity (GO:0004402) ; protein binding (GO:0005515) ; regulation of transcription, DNA-dependent (GO:0006355) ; transcription co-activator activity (GO:0003713) ; nucleus (GO:0005634) ; zinc ion binding (GO:0008270) | ||
Location | III:9766010..9775118 | ||
RNAi Phenotypes |
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External Links | |||
Associated RNAi Experiments | |||
Cenix:341-a3 | |||
Adult Phenotypes | Sterile F0/Fertility Problems |
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RNAi Reagent Name & Type | Cenix:341-a3 (PCR reagent) | ||
Delivery Method | Injection | ||
Remark | post-embryonic: Sterile F0/Fertility Problems | ||
Laboratory | TH | ||
Date | 2005-3-24 | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
JA:R10E11.1 | |||
Adult Phenotypes | Sck Ste |
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RNAi Reagent Name & Type | sjj_R10E11.1 (PCR reagent) | ||
Laboratory | JA | ||
Date | 2003-1-10 | ||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||
Simmer:R10E11.1 | |||
Embryonic Phenotypes | Emb Penetrance 100 % | ||
RNAi Reagent Name & Type | sjj_R10E11.1 (PCR reagent) | ||
Laboratory | NL | ||
Date | 2003-10-01 | ||
Strain | NL4256 rrf-3(pk1426) | ||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||
TH:321A2 | |||
Adult Phenotypes | WTDIC phenotype -- Embryonic development normal |
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RNAi Reagent Name & Type | TH:321A2 (PCR reagent) | ||
Delivery Method | Injection | ||
Laboratory | TH | ||
Date | 2000-11-16 | ||
Reference | Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." | ||
TH:341A3 | |||
Adult Phenotypes | WTDIC phenotype -- Embryonic development normal |
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RNAi Reagent Name & Type | TH:341A3 (PCR reagent) | ||
Delivery Method | Injection | ||
Laboratory | TH | ||
Date | 2000-11-16 | ||
Reference | Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." | ||
Cenix:321-a2 | |||
Adult Phenotypes | Sterile F0/Fertility Problems |
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RNAi Reagent Name & Type | Cenix:321-a2 (PCR reagent) | ||
Delivery Method | Injection | ||
Remark | early embryonic: No significant defects. | ||
Laboratory | TH | ||
Date | 2005-3-24 | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
Gene Plot of R10E11.1 | |||