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Gene/ORF R10E11.1 (cbp-1) Ace View of R10E11.1
R10E11.1 Details Help
Description  cbp-1 encodes a homolog of the mammalian transcriptional cofactors CBP (OMIM:600140) and p300 (E1A-BINDING PROTEIN, 300-KD; OMIM:602700) that have been shown to possess histone acetyltransferase activity, and which, when mutated, lead to Rubinstein-Taybi syndrome (OMIM:180849) and colorectal cancer (OMIM:114500); at least one splicing form of CBP-1 exhibits histone acetyltransferase (HAT) activity in vitro and has a glutamine/asparagine-rich domain; CBP-1 is required during embryogenesis for differentiation of all non-neuronal somatic cell types; CBP-1 is expressed very early in embryogenesis, suggesting that it may interact with maternally provided transcription factors, such as SKN-1, to specific developmental fates.
Homology Group (KOG)  CREB binding protein/P300 and related TAZ Zn-finger proteins
GO Terms  embryonic development (GO:0009790) ; regulation of transcription (GO:0045449) ; spermatogenesis (GO:0007283) ; cytoplasm (GO:0005737) ; transcription cofactor activity (GO:0003712) ; histone acetyltransferase activity (GO:0004402) ; protein binding (GO:0005515) ; regulation of transcription, DNA-dependent (GO:0006355) ; transcription co-activator activity (GO:0003713) ; nucleus (GO:0005634) ; zinc ion binding (GO:0008270)
Location   III:9766010..9775118
RNAi Phenotypes
Adult Sck ; Sterile F0/Fertility Problems ; Sterile F0/Fertility Problems ; Ste
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:341-a3
Adult Phenotypes  Sterile F0/Fertility Problems
RNAi Reagent Name & Type Cenix:341-a3 (PCR reagent)
Delivery Method  Injection
Remark  post-embryonic: Sterile F0/Fertility Problems
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:R10E11.1
Adult Phenotypes  Sck
Ste
RNAi Reagent Name & Type sjj_R10E11.1 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Simmer:R10E11.1
Embryonic Phenotypes  Emb Penetrance 100 %
RNAi Reagent Name & Type sjj_R10E11.1 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
TH:321A2
Adult Phenotypes  WTDIC phenotype -- Embryonic development normal
RNAi Reagent Name & Type TH:321A2 (PCR reagent)
Delivery Method  Injection
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
TH:341A3
Adult Phenotypes  WTDIC phenotype -- Embryonic development normal
RNAi Reagent Name & Type TH:341A3 (PCR reagent)
Delivery Method  Injection
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
Cenix:321-a2
Adult Phenotypes  Sterile F0/Fertility Problems
RNAi Reagent Name & Type Cenix:321-a2 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: No significant defects.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
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