ORF Card Page

Gene/ORF R10E11.1 (cbp-1)

R10E11.1 Details

Description

cbp-1 encodes a homolog of the mammalian transcriptional cofactors CBP (OMIM:600140) and p300 (E1A-BINDING PROTEIN, 300-KD; OMIM:602700) that have been shown to possess histone acetyltransferase activity, and which, when mutated, lead to Rubinstein-Taybi syndrome (OMIM:180849) and colorectal cancer (OMIM:114500); at least one splicing form of CBP-1 exhibits histone acetyltransferase (HAT) activity in vitro and has a glutamine/asparagine-rich domain; CBP-1 is required during embryogenesis for differentiation of all non-neuronal somatic cell types; CBP-1 is expressed very early in embryogenesis, suggesting that it may interact with maternally provided transcription factors, such as SKN-1, to specific developmental fates.

Homology Group (KOG)

CREB binding protein/P300 and related TAZ Zn-finger proteins

GO Terms

embryonic development (GO:0009790) ; regulation of transcription (GO:0045449) ; spermatogenesis (GO:0007283) ; cytoplasm (GO:0005737) ; transcription cofactor activity (GO:0003712) ; histone acetyltransferase activity (GO:0004402) ; protein binding (GO:0005515) ; regulation of transcription, DNA-dependent (GO:0006355) ; transcription co-activator activity (GO:0003713) ; nucleus (GO:0005634) ; zinc ion binding (GO:0008270)

Location

III:9766010..9775118

RNAi Phenotypes

Adult

Sck ; Sterile F0/Fertility Problems ; Sterile F0/Fertility Problems ; Ste

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