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Link to R119.6RNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentgeneMap
Gene/ORF R119.6 (taf-4) Ace View of R119.6
R119.6 Details Help
Description  taf-4 encodes a TAFII (TBP(TATA-binding protein)-associated factor) that is orthologous to human TAF4 (hTAFII130); TAF-4 is predicted to be a component of the TFIID mRNA transcription complex and is generally required for early embryonic mRNA transcription; consistent with this observation, taf-4(RNAi) results in embryonic lethality at the ~100-cell stage with little cell differentiation, similar to the loss of AMA-1/RNA polymerase II activity; TAF-4 is detected in nuclei in the adult germline, oocytes, and embryo, from the 2-cell stage through early morphogenesis.
Homology Group (KOG)  TATA box binding protein (TBP)-associated factor, RNA polymerase II
Location   I:382118..388904
RNAi Phenotypes
Postembryonic WT_postembryonic_morphology
Larva Lva ; Lvl ; Gro
Adult Unc ; Ste
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
JA:R119.6
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_R119.6 (PCR reagent)
Laboratory  JA
Date  2000-11-16
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
Simmer:R119.6:Screen_A
Embryonic Phenotypes  Emb Penetrance 100 %
Larval Phenotypes  Gro
Adult Phenotypes  Ste brood size (1 out of 5)
Unc
RNAi Reagent Name & Type sjj_R119.6 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:R119.6:Screen_B
Embryonic Phenotypes  Emb Penetrance 90 %
Larval Phenotypes  Lva
Lvl
RNAi Reagent Name & Type sjj_R119.6 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Cenix:199-b7
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  WT_postembryonic_morphology
RNAi Reagent Name & Type Cenix:199-b7 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Clear cut result.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Gene Plot of R119.6 Browse using GBrowse
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