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Gene/ORF R11E3.6 (eor-1) Ace View of R11E3.6
R11E3.6 Details Help
Description  eor-1 encodes an ortholog of the human BTB/zinc-finger transcription factor PLZF (OMIM:176797), which is is found as a retinoic acid receptor alpha (RARA) fusion in acute promyelocytic leukemia (APL); EOR-1 positively regulates RAS/RAF-mediated signalling during excretory system development, as well as RAS/RAF- and WNT-mediated signalling during P12 fate specification; EOR-1 may function with EOR-2 and Hox genes to control the expression of Ras- and Wnt-responsive genes.
Homology Group (KOG)  Zn-finger
GO Terms  Ras protein signal transduction (GO:0007265) ; Wnt receptor signaling pathway (GO:0016055) ; cell fate specification (GO:0001708) ; nucleus (GO:0005634) ; transcription factor activity (GO:0003700) ; protein binding (GO:0005515) ; nucleic acid binding (GO:0003676) ; zinc ion binding (GO:0008270)
Location   IV:4792812..4799777
RNAi Phenotypes
Larva Let
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:18-d9 (PCR reagent)
Delivery Method  Injection
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
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