Gene/ORF
T04A8.14 (emb-5)
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Ace View of T04A8.14
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T04A8.14 Details |
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Description |
emb-5 encodes the C. elegans ortholog of the Spt6 family of RNA polymerase II transcription elongation factors; first identified in screens for temperature-sensitive embryonic lethal mutations, emb-5 is required for the correct timing of the second E (endoderm)-cell division in the early embryo and thus, for normal embryonic gastrulation; in addition, emb-5 activity is required postembryonically for proper gonad development; in yeast two-hybrid studies, EMB-5 interacts with the intracellular domains of LIN-12 and GLP-1, suggesting that EMB-5 functions as a positive downstream effector in Notch-like signaling pathways during C. elegans development; emb-5 mRNA is most abundant during embryonic stages, with lower levels apparent during the L1-L3 larval stages, and even lower levels observed during L4. |
Homology Group (KOG) |
Transcription elongation factor SPT6
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GO Terms |
RNA binding
(GO:0003723) ; intracellular signaling cascade
(GO:0007242) ; hydrolase activity, acting on ester bonds
(GO:0016788) ; nucleobase, nucleoside, nucleotide and nucleic acid metabolism
(GO:0006139) |
Location |
III:4714855..4721027 |
RNAi Phenotypes |
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External Links |
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Associated RNAi Experiments |
View Details
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Wild Type RNAi Experiments |
Cenix:300-a9 |
WT |
TH:314G1 |
WT |
Experiments with Non-Wild Phenotypes |
JA:T04A8.14 |
Emb ; Sck |
Cenix:314-g1 |
Emb ; WT_postembryonic_morphology |
Gene Plot of T04A8.14 |
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