Ace View of T05H10.6 | |||||||
T05H10.6 Details | |||||||
Description | T05H10.6 encodes an ortholog of the human gene PYRUVATE DEHYDROGENASE (LIPOAMIDE) ALPHA 1 (PDHA1; OMIM:312170), which when mutated leads to Leigh syndrome (OMIM:256000); the T05H10.6 protein is predicted to be mitochondrial with 68% accuracy. | ||||||
Homology Group (KOG) | Pyruvate dehydrogenase E1, alpha subunit |
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GO Terms | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor (GO:0016624) ; metabolism (GO:0008152) | ||||||
Location | II:8065810..8068507 | ||||||
RNAi Phenotypes |
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External Links | |||||||
Associated RNAi Experiments | |||||||
Cenix:20-f8 | |||||||
Embryonic Phenotypes | Emb Penetrance None reported | ||||||
RNAi Reagent Name & Type | Cenix:20-f8 (PCR reagent) | ||||||
Delivery Method | Injection | ||||||
Remark | early embryonic: All events are significantly slowed down. | ||||||
Laboratory | TH | ||||||
Date | 2005-3-24 | ||||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||||
JA:T05H10.6 | |||||||
Embryonic Phenotypes | Emb Penetrance 80 % | ||||||
Larval Phenotypes | Gro |
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Adult Phenotypes | Clr |
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RNAi Reagent Name & Type | sjj_T05H10.6 (PCR reagent) | ||||||
Laboratory | JA | ||||||
Date | 2003-1-10 | ||||||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||||||
Gene Plot of T05H10.6 | |||||||