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Gene/ORF T05H10.6 Ace View of T05H10.6
T05H10.6 Details Help
Description  T05H10.6 encodes an ortholog of the human gene PYRUVATE DEHYDROGENASE (LIPOAMIDE) ALPHA 1 (PDHA1; OMIM:312170), which when mutated leads to Leigh syndrome (OMIM:256000); the T05H10.6 protein is predicted to be mitochondrial with 68% accuracy.
Homology Group (KOG)  Pyruvate dehydrogenase E1, alpha subunit
GO Terms  oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor (GO:0016624) ; metabolism (GO:0008152)
Location   II:8065810..8068507
RNAi Phenotypes
Early_embryo Granular cytoplasm
Larva Gro
Adult Ooc ; Clr
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:20-f8
Embryonic Phenotypes  Emb Penetrance None reported
RNAi Reagent Name & Type Cenix:20-f8 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: All events are significantly slowed down.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:T05H10.6
Embryonic Phenotypes  Emb Penetrance 80 %
Larval Phenotypes  Gro
Adult Phenotypes  Clr
RNAi Reagent Name & Type sjj_T05H10.6 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Gene Plot of T05H10.6 Browse using GBrowse
Gene Map