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Gene/ORF T06D4.4 Ace View of T06D4.4
T06D4.4 Details Help
Description  T06D4.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; T06D4.4 has no clear orthologs in other organisms.
Homology Group (KOG)  M13 family peptidase
GO Terms  neprilysin activity (GO:0004245) ; proteolysis and peptidolysis (GO:0006508) ; membrane (GO:0016020) ; metallopeptidase activity (GO:0008237)
Location   II:3391559..3395426
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:206-h7
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:206-h7 (PCR reagent)
Delivery Method  Injection
Remark  3/3 tests are wild type.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:T06D4.4
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_T06D4.4 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Gene Plot of T06D4.4 Browse using GBrowse
Gene Map