Ace View of T07A9.6 | |||
T07A9.6 Details | |||
Description | daf-18 encodes a lipid phosphatase homologous to the human PTEN tumor suppresor (OMIM:601728, mutated in Cowden disease and several cancers); DAF-18 negatively regulates insulin-like signaling mediated by DAF-2/IR and AGE-1/PI3K and thus plays a role in metabolism, development, and longevity; based on sequence and genetic analysis, DAF-18 is predicted to dephosphorylate AGE-1-generated PIP3 in order to limit activation of the downstream AKT-1 and AKT-2 kinases that negatively regulate DAF-16. | ||
Homology Group (KOG) | Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases |
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GO Terms | dauer larval development (sensu Nematoda) (GO:0040024) ; determination of adult life span (GO:0008340) ; response to heat (GO:0009408) ; negative regulation of transcription factor import into nucleus (GO:0042992) ; protein phosphatase activity (GO:0004721) ; protein amino acid dephosphorylation (GO:0006470) | ||
Location | IV:419613..425573 | ||
RNAi Phenotypes |
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External Links | |||
Associated RNAi Experiments | |||
Wild Type RNAi Experiments | |||
JA:T07A9.6 | WT | ||
Cenix:10-d6 | WT | ||
Experiments with Non-Wild Phenotypes | |||
PF:GL1_6C11 | Rup ; Pleiotropic | ||
Gene Plot of T07A9.6 | |||