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Gene/ORF T07A9.6 (daf-18) Ace View of T07A9.6
T07A9.6 Details Help
Description  daf-18 encodes a lipid phosphatase homologous to the human PTEN tumor suppresor (OMIM:601728, mutated in Cowden disease and several cancers); DAF-18 negatively regulates insulin-like signaling mediated by DAF-2/IR and AGE-1/PI3K and thus plays a role in metabolism, development, and longevity; based on sequence and genetic analysis, DAF-18 is predicted to dephosphorylate AGE-1-generated PIP3 in order to limit activation of the downstream AKT-1 and AKT-2 kinases that negatively regulate DAF-16.
Homology Group (KOG)  Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases
GO Terms  dauer larval development (sensu Nematoda) (GO:0040024) ; determination of adult life span (GO:0008340) ; response to heat (GO:0009408) ; negative regulation of transcription factor import into nucleus (GO:0042992) ; protein phosphatase activity (GO:0004721) ; protein amino acid dephosphorylation (GO:0006470)
Location   IV:419613..425573
RNAi Phenotypes
Adult Pleiotropic ; Rup
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Wild Type RNAi Experiments
JA:T07A9.6 WT
Cenix:10-d6 WT
Experiments with Non-Wild Phenotypes
PF:GL1_6C11 Rup ; Pleiotropic
Gene Plot of T07A9.6 Browse using GBrowse
Gene Map