ORF Card Page

Gene/ORF T10C6.12 (his-3)

T10C6.12 Details

Description

his-3 encodes an H2A histone; by homology, HIS-3 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-3 is a replication-dependent histone locus that resides in the HIS1 cluster on chromosome V.

GO Terms

DNA binding (GO:0003677) ; nucleosome assembly (GO:0006334) ; chromosome organization and biogenesis (sensu Eukarya) (GO:0007001) ; nucleosome (GO:0000786) ; nucleus (GO:0005634)

Location

V:16042979..16044176

RNAi Phenotypes

Early_embryo	Sister Chromatid Separation abnormal (Cross-eyed)
Larva	Lva ; Gro
Adult	Unc ; Unc ; Unc

External Links

Associated RNAi Experiments

View Details

Cenix:242-e7

Embryonic Phenotypes

Emb Penetrance None reported

Adult Phenotypes

Sister Chromatid Separation abnormal (Cross-eyed)

RNAi Reagent Name & Type

Cenix:242-e7 (PCR reagent)

Delivery Method

Injection

Remark

early embryonic: Sister Chromatid Separation (Cross-eyed)

Laboratory

Date

2005-3-24

Reference

Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."

Simmer:T10C6.12

Embryonic Phenotypes

Emb Penetrance 90 %

Larval Phenotypes

Gro

Adult Phenotypes

Unc

RNAi Reagent Name & Type

sjj_T10C6.12 (PCR reagent)

Laboratory

Date

2003-10-01

Strain

NL4256 rrf-3(pk1426)

Reference

Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."

Gene Plot of T10C6.12

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