Ace View of T20B12.2 | |||||
T20B12.2 Details | |||||
Description | tbp-1 encodes the C. elegans ortholog of the human TATA-box-binding protein (TBP; OMIM:600075; mutated in spinocerebellar ataxia 17); consistent with its proposed role in transcriptional regulation, TBP-1 has been shown to provide TFIID-like basal transcription activity in human and C. elegans extracts, to bind specifically to a TATA box sequence, and to interact with TFIIA and TFIIB transcription factors from other species; large-scale RNA-mediated interference (RNAi) screens indicate that tbp-1 activity is required for embryonic and larval development, as well as for normal rates of postembryonic growth. | ||||
Homology Group (KOG) | TATA-box binding protein (TBP), component of TFIID and TFIIIB |
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GO Terms | binding (GO:0005488) ; DNA binding (GO:0003677) ; RNA polymerase II transcription factor activity (GO:0003702) ; regulation of transcription, DNA-dependent (GO:0006355) ; transcription initiation from Pol II promoter (GO:0006367) ; nucleus (GO:0005634) ; transcription factor TFIID complex (GO:0005669) | ||||
Location | III:7383551..7386452 | ||||
RNAi Phenotypes |
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External Links | |||||
Associated RNAi Experiments | |||||
Experiments with Non-Wild Phenotypes | |||||
TH:302C7 | Emb | ||||
JA:T20B12.2 | Emb ; Gro | ||||
Cenix:340-h4 | Emb | ||||
TH:340H4 | Emb | ||||
Cenix:302-c7 | Larval Lethal-Early (L1/L2) | ||||
Simmer:T20B12.2 | Lva | ||||
Gene Plot of T20B12.2 | |||||