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Gene/ORF T20B12.8 (hmg-4) Ace View of T20B12.8
T20B12.8 Details Help
Description  hmg-4 encodes a protein with strong similarity to the highly conserved high mobility group protein SSRP1 (structure-specific DNA recognition protein); by homology, HMG-4 is predicted to be a member of the FACT (facilitates chromatin transcription) complex that functions as a transcription elongation factor; RNAi experiments indicate that hmg-4 is required for locomotion and larval development, and required redundantly with hmg-3, its paralog, for embryonic development.
Homology Group (KOG)  Nucleosome-binding factor SPN, POB3 subunit
GO Terms  DNA binding (GO:0003677) ; chromatin (GO:0000785) ; nucleus (GO:0005634) ; regulation of transcription, DNA-dependent (GO:0006355)
Location   III:7378674..7381916
RNAi Phenotypes
Early_embryo Large cytoplasmic granules ; Multiple nuclei in 1, 2, or 4-cell embryos
Postembryonic WT_postembryonic_morphology ; WT_postembryonic_morphology
Larva Lva ; Lva ; Lva ; Lvl ; Lvl ; Gro
Adult Dpy ; Bmd ; Bmd ; Pvl ; Sma ; Ste ; Ste ; Unc ; Stp
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Experiments with Non-Wild Phenotypes
Cenix:340-d12 Emb
TH:340D12 Emb
Cenix:305-h4 Emb ; WT_postembryonic_morphology
TH:312H1 Emb
Cenix:312-h1 Emb ; WT_postembryonic_morphology
Simmer:T20B12.8 Lva ; Unc
PF:GL1_1F3 Emb
Gene Plot of T20B12.8 Browse using GBrowse
Gene Map