Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
 
Link to T20H4.5.2Link to T20H4.5.1RNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
Gene/ORF T20H4.5 Ace View of T20H4.5
T20H4.5 Details Help
Description  The T20H4.5 gene encodes an ortholog of the human gene NADH DEHYDROGENASE-UBIQUINONE FE-S PROTEIN 8 23 KDA SUBUNIT; MITOCHONDRIAL COMPLEX I TYKY SUBUNIT (NDUFS8; OMIM:602141), which when mutated leads to Leigh syndrome (OMIM:256000); the T20H4.5 protein is predicted to be mitochondrial with 52% accuracy.
Homology Group (KOG)  NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit
GO Terms  electron transporter activity (GO:0005489) ; iron ion binding (GO:0005506) ; electron transport (GO:0006118) ; oxidoreductase activity, acting on NADH or NADPH (GO:0016651)
Location   III:7232450..7234526
RNAi Phenotypes
Postembryonic Larval Arrest-Early (L1/L2)
Larva Lva ; Gro
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:305-c3
Adult Phenotypes  Larval Arrest-Early (L1/L2)
RNAi Reagent Name & Type Cenix:305-c3 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: All embryos show a significant drop in the overall pace of events.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Cenix:341-d7
Embryonic Phenotypes  Emb Penetrance None reported
RNAi Reagent Name & Type Cenix:341-d7 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: x - Inadequate Test
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:T20H4.5
Embryonic Phenotypes  Emb Penetrance 100 %
Larval Phenotypes  Gro
RNAi Reagent Name & Type sjj_T20H4.5 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Simmer:T20H4.5
Embryonic Phenotypes  Emb Penetrance 50 - 80 %
Larval Phenotypes  Lva
RNAi Reagent Name & Type sjj_T20H4.5 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
TH:305C3
Embryonic Phenotypes  Emb Penetrance None reported
RNAi Reagent Name & Type TH:305C3 (PCR reagent)
Remark  Phenotype comment -- A second independent RNA (RNA2) yielded a weaker phenotype (early larval arrest).
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
TH:341D7
Embryonic Phenotypes  Emb Penetrance None reported
RNAi Reagent Name & Type TH:341D7 (PCR reagent)
Remark  Phenotype comment -- A second independent RNA (RNA2) yielded a weaker phenotype (early larval arrest).
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
Gene Plot of T20H4.5 Browse using GBrowse
Gene Map