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Gene/ORF T22B11.5 Ace View of T22B11.5
T22B11.5 Details Help
Description  The T22B11.5 gene encodes an ortholog of the human gene OGDH, which when mutated leads to alpha-ketoglutarate deficiency (OMIM:203740); the T22B11.5 protein is predicted to be mitochondrial with 68% accuracy.
Homology Group (KOG)  2-oxoglutarate dehydrogenase, E1 subunit
GO Terms  oxoglutarate dehydrogenase (lipoamide) activity (GO:0004591) ; thiamin pyrophosphate binding (GO:0030976) ; glycolysis (GO:0006096) ; oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor (GO:0016624) ; metabolism (GO:0008152)
Location   IV:4696508..4704402
RNAi Phenotypes
Postembryonic aldicarb_resistant
Larva Let ; Let ; Lva ; Gro
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:62-c10
Embryonic Phenotypes  Emb Penetrance None reported
RNAi Reagent Name & Type Cenix:62-c10 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: All events are extremely slow.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:T22B11.5
Embryonic Phenotypes  Emb Penetrance 90 %
Larval Phenotypes  Gro
RNAi Reagent Name & Type sjj_T22B11.5 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Simmer:T22B11.5
Embryonic Phenotypes  Emb Penetrance 90 %
Larval Phenotypes  Lva
RNAi Reagent Name & Type sjj_T22B11.5 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
WBRNAi00060929
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_T22B11.5 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  KP
Date  2005-5-09
Reference  Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...."
WBRNAi00060930
Adult Phenotypes  aldicarb_resistant Animals displayed resistance to paralysis on aldicarb in 7 out of 8 trials.
RNAi Reagent Name & Type sjj_T22B11.5 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  KP
Date  2005-5-09
Reference  Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...."
WBRNAi00060931
Larval Phenotypes  Let
RNAi Reagent Name & Type sjj_T22B11.5 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  KP
Date  2005-5-09
Reference  Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...."
WBRNAi00060932
Larval Phenotypes  Let
RNAi Reagent Name & Type sjj_T22B11.5 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  KP
Date  2005-5-09
Reference  Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...."
Gene Plot of T22B11.5 Browse using GBrowse
Gene Map