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Gene/ORF T22C8.8 (vab-9) Ace View of T22C8.8
T22C8.8 Details Help
Description  vab-9 encodes a claudin homolog orthologous to human brain cell membrane protein 1 (BCMP1) and Drosophila CG6982; VAB-9 colocalizes with HMP-1 to an apical layer of the adherens junctions of all epithelial cells, one layer more apically than AJM-1; vab-9 mutants have disorganized F-actin at the adherens junction, implying that VAB-9 links junctions to circumferential actin filaments; VAB-9 is also expressed in the nerve ring; VAB-9 requires the cadherin HMR-1 to localize to the cell membrane, and both alpha-catenin (HMP-1) and beta-catenin (HMP-2) to remain at the cell junction after membrane localization.
Homology Group (KOG)  Brain cell membrane protein 1 (BCMP1)
Location   II:8635757..8638034
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:150-h7
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:150-h7 (PCR reagent)
Delivery Method  Injection
Remark  Wildtype results in all three tests.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:T22C8.8
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_T22C8.8 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
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