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Gene/ORF T24D1.1 (sqv-5) Ace View of T24D1.1
T24D1.1 Details Help
Description  sqv-5 encodes a chondroitin synthase that both initiates and elongates chondroitin chains (unlike human chondroitin synthase, which only elongates them); SQV-5 is required for cytokinesis (e.g., at the one-cell embryo stage), gonad migration, and vulval morphogenesis (by expanding the extracellular space of the vulva in L4 larvae); the common requirement for SQV-5 in both processes may be to promote filling an extracellular space with fluid (either in the eggshell, or underneath the L4 cuticle); SQV-5 colocalizes with SQV-1 at punctate foci (probably the Golgi apparatus) in the cytoplasm of the vulva, the uterus and oocytes; SQV-5 is most similar to human chondroitin synthase (KIAA0990) and Drosophila CG9220.
Location   I:9947427..9953769
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:141-b8 (PCR reagent)
Delivery Method  Injection
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_T24D1.1 (PCR reagent)
Laboratory  JA
Date  2000-11-16
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
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