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Gene/ORF T26A5.9 (dlc-1) Ace View of T26A5.9
T26A5.9 Details Help
Description  dlc-1 encodes a dynein light chain type 1 that affects pronuclear migrations and thus affects embryonic viability; also affects fertility, body wall morphology and integrity.
Homology Group (KOG)  Dynein light chain type 1
GO Terms  microtubule motor activity (GO:0003777) ; microtubule-based process (GO:0007017) ; microtubule associated complex (GO:0005875)
Location   III:6462444..6464138
RNAi Phenotypes
Early_embryo Pnm ; Pnm ; Pnm ; Pnm
Postembryonic aldicarb_resistant ; WT_postembryonic_morphology ; WT_postembryonic_morphology
Larva Let ; Let ; Gro
Adult Dpy ; Dpy ; Bmd ; Bmd ; Pvl ; Unc ; Ste ; Rup
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:330-f1
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  Pnm
RNAi Reagent Name & Type Cenix:330-f1 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Pronuclear Migration
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
TH:310E9
Adult Phenotypes  WTDIC phenotype -- Embryonic development normal
RNAi Reagent Name & Type TH:310E9 (PCR reagent)
Delivery Method  Injection
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
TH:311F2
Adult Phenotypes  WTDIC phenotype -- Embryonic development normal
RNAi Reagent Name & Type TH:311F2 (PCR reagent)
Delivery Method  Injection
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
TH:330F1
Adult Phenotypes  WTDIC phenotype -- Embryonic development normal
RNAi Reagent Name & Type TH:330F1 (PCR reagent)
Delivery Method  Injection
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
Cenix:309-d6
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  Pnm
RNAi Reagent Name & Type Cenix:309-d6 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Pronuclear Migration
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Cenix:340-e6
RNAi Reagent Name & Type Cenix:340-e6 (PCR reagent)
Delivery Method  Injection
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:T26A5.9
Embryonic Phenotypes  Emb Penetrance 100 %
Adult Phenotypes  Bmd
Dpy
Rup
Ste
RNAi Reagent Name & Type sjj_T26A5.9 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Simmer:T26A5.9
Embryonic Phenotypes  Emb Penetrance 90 %
Larval Phenotypes  Gro
Adult Phenotypes  Bmd
Dpy
Pvl
Unc
RNAi Reagent Name & Type sjj_T26A5.9 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
TH:309d6
Embryonic Phenotypes  Emb Penetrance None reported
RNAi Reagent Name & Type TH:309d6 (PCR reagent)
Remark  Phenotype comment -- Confirmed with independent dsRNA (T26A5.9-RNA2; ; similar phenotype) as well as by Chris Shelton and Bruce Bowerman (personal communication).
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
TH:340e6
Embryonic Phenotypes  Emb Penetrance None reported
RNAi Reagent Name & Type TH:340e6 (PCR reagent)
Remark  Phenotype comment -- Confirmed with independent dsRNA (T26A5.9-RNA2; ; similar phenotype) as well as by Chris Shelton and Bruce Bowerman (personal communication).
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
WBRNAi00060086
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_T26A5.9 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  KP
Date  2005-5-09
Reference  Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...."
WBRNAi00060087
Adult Phenotypes  aldicarb_resistant Animals displayed resistance to paralysis on aldicarb in 4 out of 8 trials.
RNAi Reagent Name & Type sjj_T26A5.9 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  KP
Date  2005-5-09
Reference  Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...."
WBRNAi00060088
Larval Phenotypes  Let
RNAi Reagent Name & Type sjj_T26A5.9 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  KP
Date  2005-5-09
Reference  Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...."
WBRNAi00060089
Larval Phenotypes  Let
RNAi Reagent Name & Type sjj_T26A5.9 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  KP
Date  2005-5-09
Reference  Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...."
Cenix:310-e9
Adult Phenotypes  Pnm
WT_postembryonic_morphology
RNAi Reagent Name & Type Cenix:310-e9 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Pronuclear Migration
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Cenix:311-f2
Adult Phenotypes  Pnm
WT_postembryonic_morphology
RNAi Reagent Name & Type Cenix:311-f2 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Pronuclear Migration
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
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