Ace View of T28F12.2 | |||||
T28F12.2 Details | |||||
Description | unc-62 encodes a Meis-class homeodomain protein required for posterior embryonic morphogenesis, male tail morphogenesis, commissure formation by VD and DD motor neurons, vulval morphogenesis, and normal locomotion; UNC-62 is orthologous to Drosophila HOMOTHORAX; both maternal-effect unc-62 alleles and the zygotic lethal unc-62(s472) allele phenotypically resemble mutations of the caudal ortholog pal-1; RNAi of the Pbc-class ceh-20 and ceh-40 homeodomain genes strongly enhances the hypomorphic unc-62(e644) allele to give either a strong loss-of-function or null-like phenotype, while overexpression of ceh-20 enhances the lethality of some unc-62 alleles. | ||||
GO Terms | DNA binding (GO:0003677) ; transcription factor activity (GO:0003700) ; regulation of transcription, DNA-dependent (GO:0006355) ; nucleus (GO:0005634) ; regulation of transcription (GO:0045449) | ||||
Location | V:4496877..4511657 | ||||
RNAi Phenotypes |
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External Links | |||||
Associated RNAi Experiments | |||||
JA:T28F12.2a | |||||
Embryonic Phenotypes | Emb Penetrance 80 % | ||||
Adult Phenotypes | Dpy Egl Unc |
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RNAi Reagent Name & Type | sjj_T28F12.2a (PCR reagent) | ||||
Laboratory | JA | ||||
Date | 2003-1-10 | ||||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||||
Simmer:T28F12.2a | |||||
Embryonic Phenotypes | Emb Penetrance 100 % | ||||
RNAi Reagent Name & Type | sjj_T28F12.2a (PCR reagent) | ||||
Laboratory | NL | ||||
Date | 2003-10-01 | ||||
Strain | NL4256 rrf-3(pk1426) | ||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||
Cenix:155-e10 | |||||
Embryonic Phenotypes | Emb Penetrance None reported | ||||
Adult Phenotypes | WT_postembryonic_morphology |
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RNAi Reagent Name & Type | Cenix:155-e10 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Remark | early embryonic: Overall wildtype. | ||||
Laboratory | TH | ||||
Date | 2005-3-24 | ||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||
Gene Plot of T28F12.2 | |||||