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Gene/ORF T28F12.2 (unc-62) Ace View of T28F12.2
T28F12.2 Details Help
Description  unc-62 encodes a Meis-class homeodomain protein required for posterior embryonic morphogenesis, male tail morphogenesis, commissure formation by VD and DD motor neurons, vulval morphogenesis, and normal locomotion; UNC-62 is orthologous to Drosophila HOMOTHORAX; both maternal-effect unc-62 alleles and the zygotic lethal unc-62(s472) allele phenotypically resemble mutations of the caudal ortholog pal-1; RNAi of the Pbc-class ceh-20 and ceh-40 homeodomain genes strongly enhances the hypomorphic unc-62(e644) allele to give either a strong loss-of-function or null-like phenotype, while overexpression of ceh-20 enhances the lethality of some unc-62 alleles.
GO Terms  DNA binding (GO:0003677) ; transcription factor activity (GO:0003700) ; regulation of transcription, DNA-dependent (GO:0006355) ; nucleus (GO:0005634) ; regulation of transcription (GO:0045449)
Location   V:4496877..4511657
RNAi Phenotypes
Postembryonic Mig ; WT_postembryonic_morphology
Adult Ooc ; Dpy ; Egl ; Egl ; Pvl ; Unc ; Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Experiments with Non-Wild Phenotypes
Simmer:T28F12.2a Emb
Cenix:155-e10 Emb ; WT_postembryonic_morphology
JA:T28F12.2a Dpy ; Egl ; Emb ; Unc
Gene Plot of T28F12.2 Browse using GBrowse
Gene Map