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Gene/ORF VF36H2L.1 (aph-1) Ace View of VF36H2L.1
VF36H2L.1 Details Help
Description  aph-1 encodes an unfamiliar protein predicted to have seven transmembrane domains; APH-1 is a component of the GLP-1/LIN-12 (Notch) pathway, is required maternally for embryonic viability, and also affects morphogenesis, egg laying, germ line proliferation, and translocation of APH-2 to the cell surface; with PEN-2, APH-1 is required for Notch pathway signaling, gamma-secretase cleavage of beta-amyloid precursor protein, and presenilin protein accumulation.
Homology Group (KOG)  Predicted membrane protein
GO Terms  protein binding (GO:0005515) ; protein processing (GO:0016485) ; positive regulation of enzyme activity (GO:0043085) ; integral to membrane (GO:0016021)
Location   I:9231662..9233948
RNAi Phenotypes
Postembryonic WT_postembryonic_morphology
Adult Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Adult Phenotypes  Unc
RNAi Reagent Name & Type sjj_VF36H2L.1 (PCR reagent)
Laboratory  JA
Date  2000-11-16
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  WT_postembryonic_morphology
RNAi Reagent Name & Type Cenix:98-h9 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: No significant defects.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
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