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Gene/ORF W02A11.4 (uba-2) Ace View of W02A11.4
W02A11.4 Details Help
Description  uba-2 encodes the C. elegans ortholog of Saccharomyces cerevisiae Uba2p and human ubiquitin-like 2 activating enzyme E1B; by homology, UBA-2 is predicted to form, with a regulatory subunit, AOS-1, a heterodimeric enzyme that activates the ubiquitin-like protein SMO-1/SUMO in preparation for its covalent attachment to target proteins to regulate their subcellular localization and/or stability; in C. elegans, UBA-2 is required for embryogenesis and vulval development, as well as for proper Hox gene regulation; uba-2/aos-1(RNAi) animals that survive embryogenesis show ectopic expression of EGL-5 and ectopic anterior sensory ray formation.
Homology Group (KOG)  SMT3/SUMO-activating complex, catalytic component UBA2
GO Terms  catalytic activity (GO:0003824) ; ubiquitin activating enzyme activity (GO:0004839) ; protein modification (GO:0006464) ; ubiquitin cycle (GO:0006512) ; ubiquitin-like activating enzyme activity (GO:0008642)
Location   I:12741192..12745688
RNAi Phenotypes
Postembryonic WT_postembryonic_morphology ; Vul
Larva Lva ; Lva ; Lva ; Gro
Adult Egl ; Pvl ; Pvl ; Pvl ; Ste ; Unc ; Stp
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Experiments with Non-Wild Phenotypes
JA:W02A11.4 Egl ; Pvl ; Vul
Simmer:W02A11.4:Screen_B Emb ; Lva ; Pvl ; Stp ; Unc
Simmer:W02A11.4:Screen_A Lva ; Pvl
Cenix:76-c5 Emb ; WT_postembryonic_morphology
Gene Plot of W02A11.4 Browse using GBrowse
Gene Map