Ace View of W02A11.4 | |||||||
W02A11.4 Details | |||||||
Description | uba-2 encodes the C. elegans ortholog of Saccharomyces cerevisiae Uba2p and human ubiquitin-like 2 activating enzyme E1B; by homology, UBA-2 is predicted to form, with a regulatory subunit, AOS-1, a heterodimeric enzyme that activates the ubiquitin-like protein SMO-1/SUMO in preparation for its covalent attachment to target proteins to regulate their subcellular localization and/or stability; in C. elegans, UBA-2 is required for embryogenesis and vulval development, as well as for proper Hox gene regulation; uba-2/aos-1(RNAi) animals that survive embryogenesis show ectopic expression of EGL-5 and ectopic anterior sensory ray formation. | ||||||
Homology Group (KOG) | SMT3/SUMO-activating complex, catalytic component UBA2 |
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GO Terms | catalytic activity (GO:0003824) ; ubiquitin activating enzyme activity (GO:0004839) ; protein modification (GO:0006464) ; ubiquitin cycle (GO:0006512) ; ubiquitin-like activating enzyme activity (GO:0008642) | ||||||
Location | I:12741192..12745688 | ||||||
RNAi Phenotypes |
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External Links | |||||||
Associated RNAi Experiments | |||||||
Experiments with Non-Wild Phenotypes | |||||||
JA:W02A11.4 | Egl ; Pvl ; Vul | ||||||
Simmer:W02A11.4:Screen_B | Emb ; Lva ; Pvl ; Stp ; Unc | ||||||
Simmer:W02A11.4:Screen_A | Lva ; Pvl | ||||||
Cenix:76-c5 | Emb ; WT_postembryonic_morphology | ||||||
Gene Plot of W02A11.4 | |||||||