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Gene/ORF W02B9.1 (hmr-1) Ace View of W02B9.1
W02B9.1 Details Help
Description  hmr-1 encodes two isoforms of a classical cadherin that contain extracellular cadherin, EGF-like, and laminin G domains as well as a highly conserved intracellular domain that binds beta-catenin; by homology, the HMR-1 proteins are predicted to function as calcium-dependent, homophilic cell-cell adhesion receptors; in vivo, HMR-1A activity is required for mediating the cell migrations, cell shape changes, and presumably actin cytoskeleton rearrangements that occur during embryonic morphogenesis; HMR-1B is required for fasciculation and outgrowth of a subset of motor neuron processes; HMR-1 antibodies detect expression in all embryonic blastomeres at early stages of development but as hypodermal adherens junctions form and morphogenesis begins, HMR-1 becomes highly expressed in the apical junctions of all hypodermal cells; later, HMR-1 is expressed primarily at the apical margins of hypodermal, pharyngeal, and intestinal cells in a pattern consistent with localization to adherens junctions; an HMR-1B reporter fusion is expressed in neurons, including the DD, VD, and AS class of motor neurons; HMR-1 activity is required for proper localization of other junctional components, such as HMP-1/alpha-catenin and HMP-2/beta-catenin, but not for localization of AJM-1, the junctional component recognized by the MH27 antibody.
Homology Group (KOG)  Cadherin repeats
GO Terms  embryonic development (GO:0009790) ; cell migration (GO:0016477) ; cytoskeletal anchoring (GO:0007016) ; cell-cell adherens junction (GO:0005913) ; protein binding (GO:0005515) ; calcium ion binding (GO:0005509) ; homophilic cell adhesion (GO:0007156) ; membrane (GO:0016020)
Location   I:11075349..11135058
RNAi Phenotypes
Postembryonic WT_postembryonic_morphology
Adult Dpy ; Bmd ; Ste ; Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Wild Type RNAi Experiments
Cenix:81-f1 WT
JA:Y52B11B.2 WT
JA:ZK39.1 WT
Cenix:172-e4 WT
Experiments with Non-Wild Phenotypes
Simmer:W02B9.1:Screen_A Emb ; Ste
JA:W02B9.1 Bmd ; Dpy ; Emb ; Unc
Simmer:W02B9.1:Screen_B Emb
Cenix:141-f9 Emb ; WT_postembryonic_morphology
Gene Plot of W02B9.1 Browse using GBrowse
Gene Map