Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
 
Link to W02D3.12Link to W02D3.9.1Link to W02D3.9.2RNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
Gene/ORF W02D3.9 (unc-37) Ace View of W02D3.9
W02D3.9 Details Help
Description  The unc-37 gene encodes a transducin-like WD-repeat protein homologous to Drosophila GROUCHO that genetically interacts with components of the transcriptional Mediator complex.
Homology Group (KOG)  Transducin-like enhancer of split protein (contains WD40 repeats)
GO Terms  negative regulation of transcription (GO:0016481) ; regulation of neurotransmitter levels (GO:0001505) ; synaptic transmission (GO:0007268) ; regulation of synapse structure and function (GO:0050803) ; regulation of axonogenesis (GO:0050770) ; nucleus (GO:0005634) ; transcription co-repressor activity (GO:0003714) ; frizzled signaling pathway (GO:0007222) ; regulation of transcription (GO:0045449)
Location   I:6741897..6745740
RNAi Phenotypes
Early_embryo Large cytoplasmic granules ; Pnm
Larva Let
Adult Ooc ; Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:13-h5
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  Pnm
RNAi Reagent Name & Type Cenix:13-h5 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Pronuclear Migration
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:W02D3.9
Embryonic Phenotypes  Emb Penetrance 100 %
Adult Phenotypes  Unc
RNAi Reagent Name & Type sjj_W02D3.9 (PCR reagent)
Laboratory  JA
Date  2000-11-16
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
PF:GL1_8H2
Embryonic Phenotypes  Emb Penetrance 100 %
Adult Phenotypes  Large cytoplasmic granules
RNAi Reagent Name & Type sjj_W02D3.9 (PCR reagent)
Delivery Method  Injection
Remark  PCR product contains flanking T7 promoter sequences
Laboratory  KK
Date  2002-11-19
Reference  Piano et al. (2002) Curr Biol "Gene Clustering Based on RNAi Phenotypes of Ovary-Enriched Genes in C. elegans"
Movies/Stacks/Images  /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif
Simmer:W02D3.9:Screen_A
Embryonic Phenotypes  Emb Penetrance 100 %
RNAi Reagent Name & Type sjj_W02D3.9 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:W02D3.9:Screen_B
Embryonic Phenotypes  Emb Penetrance 100 %
RNAi Reagent Name & Type sjj_W02D3.9 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Gene Plot of W02D3.9 Browse using GBrowse
Gene Map