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Gene/ORF W02G9.1 (ndx-2) Ace View of W02G9.1
W02G9.1 Details Help
Description  ndx-2 encodes a NUDIX hydrolase; by sequence comparison, NDX-2 is predicted to be orthologous to human NUDT5 which, in vitro, possesses ADP-sugar diphosphatase activity; in C. elegans, loss of ndx-2 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, consistent with the proposed nonessential roles for Nudix proteins in eliminating potentially toxic nucleotide metabolites from cells and modulating levels of metabolic intermediates by shuttling them into alternative biochemical pathways.
Homology Group (KOG)  Nucleoside diphosphate-sugar hydrolase of the MutT (NUDIX) family
Location   V:2662508..2665230
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:135-f4 (PCR reagent)
Delivery Method  Injection
Remark  3/3 wild type
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_W02G9.1 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
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