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Gene/ORF W03C9.3 (rab-7) Ace View of W03C9.3
W03C9.3 Details Help
Description  rab-7 encodes a small GTPase homologous to the Rab GTPases that function in endocytosis, membrane fusion, and vesicular trafficking events; RAB-7 is required for proper yolk protein localization in oocytes, and for embryogenesis, locomotion, and normal body morphology; by sequence similarity, RAB-7 is predicted to be a late endosome component.
Homology Group (KOG)  Ras-related GTPase
GO Terms  endocytosis (GO:0006897) ; oocyte growth (GO:0001555) ; cellular_component unknown (GO:0008372) ; GTPase activity (GO:0003924) ; GTP binding (GO:0005525) ; small GTPase mediated signal transduction (GO:0007264) ; protein transport (GO:0015031) ; DNA binding (GO:0003677) ; two-component signal transduction system (phosphorelay) (GO:0000160) ; regulation of transcription, DNA-dependent (GO:0006355)
Location   II:11964727..11967238
RNAi Phenotypes
Early_embryo Integrity of Membranous Organelles defective ; Cytokinesis problems
Postembryonic Prz
Adult Dpy ; Dpy ; Bmd ; Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:143-e7
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  Integrity of Membranous Organelles defective
RNAi Reagent Name & Type Cenix:143-e7 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Integrity of Membranous Organelles
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:W03C9.3
Embryonic Phenotypes  Emb Penetrance 40 %
Adult Phenotypes  Bmd
Dpy
Adult Phenotypes  Prz
RNAi Reagent Name & Type sjj_W03C9.3 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Simmer:W03C9.3
Embryonic Phenotypes  Emb Penetrance 50 - 80 %
Adult Phenotypes  Dpy
Unc
RNAi Reagent Name & Type sjj_W03C9.3 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
[cgc5655]:W03C9.3
Adult Phenotypes  Unclassified lipid metabolism abnormal
RNAi Reagent Name & Type sjj_W03C9.3 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  GR
Date  2003-1-10
Reference  Ashrafi K et al. (2003) Nature "Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory ...."
[cgc5655]:daf-2:W03C9.3
Adult Phenotypes  WTRNAi causes no change in fat content
RNAi Reagent Name & Type sjj_W03C9.3 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  GR
Date  2003-1-10
Strain  daf-2(e1370)
Reference  Ashrafi K et al. (2003) Nature "Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory ...."
[cgc5655]:tph-1:W03C9.3
Adult Phenotypes  Unclassified lipid metabolism abnormal
RNAi Reagent Name & Type sjj_W03C9.3 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  GR
Date  2003-1-10
Strain  tph-1(mg280)
Reference  Ashrafi K et al. (2003) Nature "Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory ...."
[cgc5655]:tub-1:W03C9.3
Adult Phenotypes  WTRNAi causes no change in fat content
RNAi Reagent Name & Type sjj_W03C9.3 (PCR reagent)
Delivery Method  Bacterial_feeding
Laboratory  GR
Date  2003-1-10
Strain  tub-1(nr2004)
Reference  Ashrafi K et al. (2003) Nature "Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory ...."
Gene Plot of W03C9.3 Browse using GBrowse
Gene Map