Ace View of W03C9.3 | |||||||
W03C9.3 Details | |||||||
Description | rab-7 encodes a small GTPase homologous to the Rab GTPases that function in endocytosis, membrane fusion, and vesicular trafficking events; RAB-7 is required for proper yolk protein localization in oocytes, and for embryogenesis, locomotion, and normal body morphology; by sequence similarity, RAB-7 is predicted to be a late endosome component. | ||||||
Homology Group (KOG) | Ras-related GTPase |
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GO Terms | endocytosis (GO:0006897) ; oocyte growth (GO:0001555) ; cellular_component unknown (GO:0008372) ; GTPase activity (GO:0003924) ; GTP binding (GO:0005525) ; small GTPase mediated signal transduction (GO:0007264) ; protein transport (GO:0015031) ; DNA binding (GO:0003677) ; two-component signal transduction system (phosphorelay) (GO:0000160) ; regulation of transcription, DNA-dependent (GO:0006355) | ||||||
Location | II:11964727..11967238 | ||||||
RNAi Phenotypes |
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External Links | |||||||
Associated RNAi Experiments | |||||||
Cenix:143-e7 | |||||||
Embryonic Phenotypes | Emb Penetrance None reported | ||||||
Adult Phenotypes | Integrity of Membranous Organelles defective |
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RNAi Reagent Name & Type | Cenix:143-e7 (PCR reagent) | ||||||
Delivery Method | Injection | ||||||
Remark | early embryonic: Integrity of Membranous Organelles | ||||||
Laboratory | TH | ||||||
Date | 2005-3-24 | ||||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||||
JA:W03C9.3 | |||||||
Embryonic Phenotypes | Emb Penetrance 40 % | ||||||
Adult Phenotypes | Bmd Dpy |
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Adult Phenotypes | Prz |
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RNAi Reagent Name & Type | sjj_W03C9.3 (PCR reagent) | ||||||
Laboratory | JA | ||||||
Date | 2003-1-10 | ||||||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||||||
Simmer:W03C9.3 | |||||||
Embryonic Phenotypes | Emb Penetrance 50 - 80 % | ||||||
Adult Phenotypes | Dpy Unc |
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RNAi Reagent Name & Type | sjj_W03C9.3 (PCR reagent) | ||||||
Laboratory | NL | ||||||
Date | 2003-10-01 | ||||||
Strain | NL4256 rrf-3(pk1426) | ||||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||||
[cgc5655]:W03C9.3 | |||||||
Adult Phenotypes | Unclassified
lipid metabolism abnormal |
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RNAi Reagent Name & Type | sjj_W03C9.3 (PCR reagent) | ||||||
Delivery Method | Bacterial_feeding | ||||||
Laboratory | GR | ||||||
Date | 2003-1-10 | ||||||
Reference | Ashrafi K et al. (2003) Nature "Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory ...." | ||||||
[cgc5655]:daf-2:W03C9.3 | |||||||
Adult Phenotypes | WTRNAi causes no change in fat content |
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RNAi Reagent Name & Type | sjj_W03C9.3 (PCR reagent) | ||||||
Delivery Method | Bacterial_feeding | ||||||
Laboratory | GR | ||||||
Date | 2003-1-10 | ||||||
Strain | daf-2(e1370) | ||||||
Reference | Ashrafi K et al. (2003) Nature "Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory ...." | ||||||
[cgc5655]:tph-1:W03C9.3 | |||||||
Adult Phenotypes | Unclassified
lipid metabolism abnormal |
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RNAi Reagent Name & Type | sjj_W03C9.3 (PCR reagent) | ||||||
Delivery Method | Bacterial_feeding | ||||||
Laboratory | GR | ||||||
Date | 2003-1-10 | ||||||
Strain | tph-1(mg280) | ||||||
Reference | Ashrafi K et al. (2003) Nature "Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory ...." | ||||||
[cgc5655]:tub-1:W03C9.3 | |||||||
Adult Phenotypes | WTRNAi causes no change in fat content |
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RNAi Reagent Name & Type | sjj_W03C9.3 (PCR reagent) | ||||||
Delivery Method | Bacterial_feeding | ||||||
Laboratory | GR | ||||||
Date | 2003-1-10 | ||||||
Strain | tub-1(nr2004) | ||||||
Reference | Ashrafi K et al. (2003) Nature "Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory ...." | ||||||
Gene Plot of W03C9.3 | |||||||