Ace View of W05E10.3 | |||||
W05E10.3 Details | |||||
Description | ceh-32 encodes a Six/sine oculis-type homeodomain protein most closely related to the Six3/6 subfamily that contains Drosophila OPTIX and human SIX3 (OMIM:603714, which when mutated leads to holoprosencephaly 2); CEH-32 appears to be essential for development and required for proper head morphogenesis; during embryogenesis, CEH-32 is expressed in hypodermal and neuronal precursors, and at later stages, in the descendants of these cells and in gonadal sheath cells; in some hypodermal cells, ceh-32 is a direct transcriptional target of VAB-3, a PAX-6 ortholog sufficient to induce ceh-32 expression in some cell types and able to bind the ceh-32 promoter in vitro. | ||||
Homology Group (KOG) | Transcription factor SIX and related HOX domain proteins |
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GO Terms | post-embryonic morphogenesis (GO:0009886) ; regulation of transcription (GO:0045449) ; nucleus (GO:0005634) ; transcription factor activity (GO:0003700) ; DNA binding (GO:0003677) ; regulation of transcription, DNA-dependent (GO:0006355) ; development (GO:0007275) | ||||
Location | V:11703951..11708391 | ||||
RNAi Phenotypes |
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External Links | |||||
Associated RNAi Experiments | |||||
Cenix:141-d10 | |||||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | Cenix:141-d10 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Laboratory | TH | ||||
Date | 2005-3-24 | ||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||
JA:W05E10.3 | |||||
Adult Phenotypes | Unc |
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RNAi Reagent Name & Type | sjj_W05E10.3 (PCR reagent) | ||||
Laboratory | JA | ||||
Date | 2003-1-10 | ||||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||||
Simmer:W05E10.3 | |||||
Embryonic Phenotypes | Emb Penetrance 20 - 40 % | ||||
Larval Phenotypes | Lva |
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Adult Phenotypes | Unc |
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RNAi Reagent Name & Type | sjj_W05E10.3 (PCR reagent) | ||||
Laboratory | NL | ||||
Date | 2003-10-01 | ||||
Strain | NL4256 rrf-3(pk1426) | ||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||
Gene Plot of W05E10.3 | |||||