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Gene/ORF W05E10.3 (ceh-32) Ace View of W05E10.3
W05E10.3 Details Help
Description  ceh-32 encodes a Six/sine oculis-type homeodomain protein most closely related to the Six3/6 subfamily that contains Drosophila OPTIX and human SIX3 (OMIM:603714, which when mutated leads to holoprosencephaly 2); CEH-32 appears to be essential for development and required for proper head morphogenesis; during embryogenesis, CEH-32 is expressed in hypodermal and neuronal precursors, and at later stages, in the descendants of these cells and in gonadal sheath cells; in some hypodermal cells, ceh-32 is a direct transcriptional target of VAB-3, a PAX-6 ortholog sufficient to induce ceh-32 expression in some cell types and able to bind the ceh-32 promoter in vitro.
Homology Group (KOG)  Transcription factor SIX and related HOX domain proteins
GO Terms  post-embryonic morphogenesis (GO:0009886) ; regulation of transcription (GO:0045449) ; nucleus (GO:0005634) ; transcription factor activity (GO:0003700) ; DNA binding (GO:0003677) ; regulation of transcription, DNA-dependent (GO:0006355) ; development (GO:0007275)
Location   V:11703951..11708391
RNAi Phenotypes
Larva Lva ; Lva
Adult Sck ; Unc ; Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:141-d10
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:141-d10 (PCR reagent)
Delivery Method  Injection
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:W05E10.3
Adult Phenotypes  Unc
RNAi Reagent Name & Type sjj_W05E10.3 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Simmer:W05E10.3
Embryonic Phenotypes  Emb Penetrance 20 - 40 %
Larval Phenotypes  Lva
Adult Phenotypes  Unc
RNAi Reagent Name & Type sjj_W05E10.3 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Gene Plot of W05E10.3 Browse using GBrowse
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