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Gene/ORF Y116A8C.42 (snr-1) Ace View of Y116A8C.42
Y116A8C.42 Details Help
Description  snr-1 encodes an ortholog of human small nuclear ribonucleoprotein Sm D3, a protein that forms part of a heptameric complex required for the biogenesis and function of the snRNPs that catalyze mRNA splicing; in combination with the gene that encodes the human Sm B ortholog (snr-2) snr-1 affects embryonic viability and the nuclear association and localization of P granules in embryos based on an RNAi assay, and also affects embryonic viability, growth, and fertility based on large-scale RNAi assays; snr-1 is expressed in embryos and is expressed in larvae and adults in muscles of the alimentary system, in body-wall muscle, in seam cells and other unidentified cells in larvae and in adults.
Homology Group (KOG)  Small nuclear ribonucleoprotein Sm D3
GO Terms  mRNA processing (GO:0006397) ; ribonucleoprotein complex (GO:0030529) ; nucleus (GO:0005634) ; small nucleolar ribonucleoprotein complex (GO:0005732)
Location   IV:17087610..17089191
RNAi Phenotypes
Early_embryo Osmotic Integrity defective
Larva Lva ; Gro
Adult Sck ; Ste ; Ste ; Ste
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:38-f4
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  Osmotic Integrity defective
RNAi Reagent Name & Type Cenix:38-f4 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Osmotic Integrity
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:Y116A8C.42
Embryonic Phenotypes  Emb Penetrance 90 %
Larval Phenotypes  Gro
Adult Phenotypes  Sck
Ste
RNAi Reagent Name & Type sjj_Y116A8C.42 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Simmer:Y116A8C.42
Adult Phenotypes  Ste
RNAi Reagent Name & Type sjj_Y116A8C.42 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
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