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Gene/ORF Y39A1B.3 (dpy-28) Ace View of Y39A1B.3
Y39A1B.3 Details Help
Description  dpy-28 encodes a non-SMC condensin subunit homolog, similar to XCAP-D2 in Xenopus, Cnd1 in S. pombe, and Ycs4p in S. cerevisiae, that is required for negative, chromosome-wide regulation of X-chromosomal genes in XX but not XO animals (dosage compensation), and for some undetermined aspect of body morphogenesis; DPY-28 is part of a multiprotein 'dosage compensation' complex with DPY-26, DPY-27 and MIX-1.
Homology Group (KOG)  Chromosome condensation complex Condensin, subunit D2
GO Terms  binding (GO:0005488) ; mitosis (GO:0007067) ; chromosome condensation (GO:0030261) ; nucleus (GO:0005634)
Location   III:10762624..10777204
RNAi Phenotypes
Larva Gro
Adult Dpy ; Dpy ; Dpy ; Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:321-g8
RNAi Reagent Name & Type Cenix:321-g8 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: No significant defects. 1/5 embryos is osmotic sensitive.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Cenix:337-b10
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:337-b10 (PCR reagent)
Delivery Method  Injection
Remark  wild type
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:Y39A1B.3
Embryonic Phenotypes  Emb Penetrance 10 %
Adult Phenotypes  Dpy
Unc
RNAi Reagent Name & Type sjj_Y39A1B.3 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Simmer:Y39A1B.3
Embryonic Phenotypes  Emb Penetrance 20 - 40 %
Larval Phenotypes  Gro
Adult Phenotypes  Dpy
RNAi Reagent Name & Type sjj_Y39A1B.3 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
TH:321G8
Adult Phenotypes  Dpy
RNAi Reagent Name & Type TH:321G8 (PCR reagent)
Remark  Phenotype comment -- Not yet confirmed by independent RNA
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
TH:337B10
Adult Phenotypes  WTDIC phenotype -- Embryonic development normal
RNAi Reagent Name & Type TH:337B10 (PCR reagent)
Delivery Method  Injection
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
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