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Gene/ORF Y39A3CR.4 (ddp-1) Ace View of Y39A3CR.4
Y39A3CR.4 Details Help
Description  ddp-1 encodes the C. elegans ortholog of Saccharomyces cerevisiae Tim8p and human deafness/dystonia peptide (DDP; OMIM:300356, mutated in Mohr-Tranebjaerg syndrome); by homology, DDP-1 is predicted to be part of a heterooligomeric complex that localizes to the mitochondrial intermembrane space and facilitates translocation of proteins from the cytosol to the inner mitochondrial membrane; loss of ddp-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, indicating that ddp-1 is not essential for C. elegans development or may function redundantly with its paralogs, TIN-9, -10, and -13.
Homology Group (KOG)  Mitochondrial import inner membrane translocase, subunit TIM8
GO Terms  protein-mitochondrial targeting (GO:0006626) ; mitochondrial inner membrane protein import (GO:0045039) ; mitochondrial inner membrane protein insertion complex (GO:0042721)
Location   III:1859480..1860715
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:214-d1
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:214-d1 (PCR reagent)
Delivery Method  Injection
Remark  Wildtype results in all three tests.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:Y39A3C_83.d
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_Y39A3C_83.d (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
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