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Gene/ORF Y39G10AL.3 (cdk-7) Ace View of Y39G10AL.3
Y39G10AL.3 Details Help
Description  The cdk-7 gene encodes a cyclin-dependent kinase orthologous to human CDK7 (OMIM:601955) that is a component of the general transcription factor IIH (TFIIH) complex; CDK-7 is required during embryogenesis for mRNA transcription and phosphorylation of RNA polymerase II on serine 2 and serine 5, as well as for cell cycle progression, maintenance of ploidy, and completion of meiosis following fertilization.
Homology Group (KOG)  Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, kinase subunit CDK7
GO Terms  mitotic cell cycle, embryonic (GO:0045448) ; protein amino acid phosphorylation (GO:0006468) ; mRNA transcription (GO:0009299) ; cellular_component unknown (GO:0008372) ; cyclin-dependent protein kinase activity (GO:0004693) ; protein kinase activity (GO:0004672) ; ATP binding (GO:0005524) ; protein serine/threonine kinase activity (GO:0004674)
Location   I:2281138..2291584
RNAi Phenotypes
Postembryonic WT_postembryonic_morphology
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:189-h3
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  WT_postembryonic_morphology
RNAi Reagent Name & Type Cenix:189-h3 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Clear-cut result.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
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