ORF Card Page

Gene/ORF Y43F4B.6 (klp-19)

Y43F4B.6 Details

Description

klp-19 encodes a plus-end-directed microtubule motor protein that is most closely related to motors of the kinesin-4 family; KLP-19 activity is essential for embryonic and larval development and is required for generating a force that aligns sister chromatid kinetochores directly opposite the spindle poles thus ensuring proper holocentric chromosome segregation; KLP-19 expression is detected in embryos and in the gonad, where it is most strongly expressed in distal mitotic nuclei and in late meiotic prophase nucleoplasm; during meiosis and mitosis, KLP-19 expression is dynamic and is detected in the nucleoplasm, the spindle body, in association with condensed chromosomes (particularly between homologous chromosomes), and in the spindle interzone.

Homology Group (KOG)

Kinesin-like protein

GO Terms

microtubule motor activity (GO:0003777) ; ATP binding (GO:0005524) ; microtubule-based movement (GO:0007018) ; microtubule associated complex (GO:0005875)

Location

III:13301859..13307175

RNAi Phenotypes