ORF Card Page

Gene/ORF Y45G12B.1 (nuo-5)

Y45G12B.1 Details

Description

Y45G12B.1 is orthologous to human NADH-UBIQUINONE OXIDOREDUCTASE Fe-S PROTEIN 1 (NDUFS1; OMIM:157655), which when mutated leads to mitochondrial complex I deficiency.

GO Terms

NADH dehydrogenase (ubiquinone) activity (GO:0008137) ; mitochondrial electron transport, NADH to ubiquinone (GO:0006120) ; electron transporter activity (GO:0005489) ; iron ion binding (GO:0005506) ; electron transport (GO:0006118) ; oxidoreductase activity (GO:0016491) ; oxidoreductase activity, acting on NADH or NADPH (GO:0016651)

Location

V:2698399..2707251

RNAi Phenotypes

Postembryonic	WT_postembryonic_morphology
Larva	Lva ; Gro

External Links

Associated RNAi Experiments

View Summary

JA:Y45G12B.1

Embryonic Phenotypes

Emb Penetrance 40 %

Larval Phenotypes

Gro

RNAi Reagent Name & Type

sjj_Y45G12B.1 (PCR reagent)

Laboratory

Date

2003-1-10

Reference

Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."

Simmer:Y45G12B.1

Larval Phenotypes

Lva

RNAi Reagent Name & Type

sjj_Y45G12B.1 (PCR reagent)

Laboratory

Date

2003-10-01

Strain

NL4256 rrf-3(pk1426)

Reference

Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."

Cenix:142-e3

Embryonic Phenotypes

Emb Penetrance None reported

Adult Phenotypes

WT_postembryonic_morphology

RNAi Reagent Name & Type

Cenix:142-e3 (PCR reagent)

Delivery Method

Injection

Remark

early embryonic: No significant defects.

Laboratory

Date

2005-3-24

Reference

Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."

Gene Plot of Y45G12B.1

Browse using GBrowse