| Description |
Y46G5A.19 encodes a spermidine synthase ortholog coexpressed in intestinal cells with smd-1 and odc-1; Y46G5A.19, smd-1 and odc-1, on the basis of orthology, are expected to be required for spermidine synthesis; while none of these three genes have obvious functions in mass RNAi assays, a loss-of-function mutation of odc-1 is lethal; the Y46G5A.19 promoter has GATA- and initiator-(Inr)-like-elements that are conserved with its C. briggsae ortholog, and that are also found in the C. elegans and C. briggsae smd-1 promoters; the Inr-like-element of Y46G5A.19 is not its main transcriptional start site; unlike other metazoa, C. elegans lacks a spermine synthase ortholog. |
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