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Gene/ORF Y47D3B.7 (sbp-1) Ace View of Y47D3B.7
Y47D3B.7 Details Help
Description  sbp-1 encodes a basic helix-loop-helix (bHLH) transcription factor homologous to the mammalian Sterol Regulatory Element Binding Proteins (SREBPs, OMIM:184756, overexpression of nuclear form of SREBP-1c is associated with insulin resistance and features of congenital generalized lipodystrophy); in C. elegans, SBP-1 activity is required for normal lipid metabolism and wild-type levels of lipogenic enzyme expression, as well as for embryonic and larval development; sbp-1 expression is detected exclusively in the intestine, the major site of fat storage, from early embryogenesis through adulthood.
Homology Group (KOG)  Predicted DNA-binding protein
GO Terms  transcription regulator activity (GO:0030528) ; regulation of transcription (GO:0045449) ; nucleus (GO:0005634)
Location   III:11427841..11442842
RNAi Phenotypes
Postembryonic Lpd ; Larval Lethal-Early (L1/L2)
Larva Lva ; Lva ; Gro ; Gro ; Gro
Adult Bmd ; Bmd ; Clr ; Sck ; Stp
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Experiments with Non-Wild Phenotypes
Cenix:325-g3 Larval Lethal-Early (L1/L2)
JA:Y47D3B.7 Clr ; Gro ; Sck ; Stp
[cgc5655]:Y47D3B.7 Unclassified
[cgc5655]:tph-1:Y47D3B.7 Unclassified
[cgc5655]:daf-2:Y47D3B.7 Unclassified
TH:341C8 Bmd ; Gro
TH:325G3 Bmd ; Gro
[cgc5707]:lpd-1 Lpd ; Unclassified
Cenix:341-c8
Simmer:Y47D3B.7 Lva
[cgc5655]:tub-1:Y47D3B.7 Unclassified
Gene Plot of Y47D3B.7 Browse using GBrowse
Gene Map