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Gene/ORF Y48B6A.8 (ace-3) Ace View of Y48B6A.8
Y48B6A.8 Details Help
Description  ace-3 encodes one of four C. elegans acetylcholinesterases (AChE); ACE-3 represents ~5% of the total AChE activity in C. elegans and in vitro, hydrolyzes acetylthio-, butyrylthio-, and propionylthiocholine substrates with equal efficiency; although loss-of-function mutations in ace-3 result in no obvious defects, animals doubly mutant with ace-1 or ace-2 have slight defects in backward locomotion and animals triply mutant for ace-1, -2, and -3 arrest as unhatched, yet fully developed, embryos; ace-3 is the downstream gene in an operon with a fourth AChE-encoding gene, ace-4, and transcriptional reporter fusions with ace-4 upstream sequences direct expression in pharyngeal muscles pm3, 4, 5, and 7, the two CAN (canal associated neuron) cells, midbody dorsal body wall muscles in larvae, and several neurons in the head and anal ganglion
Homology Group (KOG)  Acetylcholinesterase/Butyrylcholinesterase
GO Terms  acetylcholine catabolism (GO:0006581) ; regulation of backward locomotion (GO:0043058) ; hatching (GO:0035188) ; organismal movement (GO:0050879) ; larval development (sensu Nematoda) (GO:0002119) ; acetylcholinesterase activity (GO:0003990) ; acetylcholine binding (GO:0042166) ; cholinesterase activity (GO:0004104) ; catalytic activity (GO:0003824)
Location   II:14205126..14210473
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Wild Type RNAi Experiments
JA:Y119D3_455.a WT
JA:Y48B6A.8 WT
Cenix:72-f11 WT
Gene Plot of Y48B6A.8 Browse using GBrowse
Gene Map