ORF Card Page


Gene/ORF Y48B6A.8 (ace-3)	Ace View of Y48B6A.8
Y48B6A.8 Details
Description	ace-3 encodes one of four C. elegans acetylcholinesterases (AChE); ACE-3 represents ~5% of the total AChE activity in C. elegans and in vitro, hydrolyzes acetylthio-, butyrylthio-, and propionylthiocholine substrates with equal efficiency; although loss-of-function mutations in ace-3 result in no obvious defects, animals doubly mutant with ace-1 or ace-2 have slight defects in backward locomotion and animals triply mutant for ace-1, -2, and -3 arrest as unhatched, yet fully developed, embryos; ace-3 is the downstream gene in an operon with a fourth AChE-encoding gene, ace-4, and transcriptional reporter fusions with ace-4 upstream sequences direct expression in pharyngeal muscles pm3, 4, 5, and 7, the two CAN (canal associated neuron) cells, midbody dorsal body wall muscles in larvae, and several neurons in the head and anal ganglion
Homology Group (KOG)	Acetylcholinesterase/Butyrylcholinesterase
GO Terms	acetylcholine catabolism (GO:0006581) ; regulation of backward locomotion (GO:0043058) ; hatching (GO:0035188) ; organismal movement (GO:0050879) ; larval development (sensu Nematoda) (GO:0002119) ; acetylcholinesterase activity (GO:0003990) ; acetylcholine binding (GO:0042166) ; cholinesterase activity (GO:0004104) ; catalytic activity (GO:0003824)
Location	II:14205126..14210473
RNAi Phenotypes	No phenotypes observed.
External Links
Associated RNAi Experiments	View Summary
Cenix:72-f11
Adult Phenotypes	WT
RNAi Reagent Name & Type	Cenix:72-f11 (PCR reagent)
Delivery Method	Injection
Remark	early embryonic: No significant defects detected.
Laboratory	TH
Date	2005-3-24
Reference	Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:Y119D3_455.a
Adult Phenotypes	WT
RNAi Reagent Name & Type	sjj_Y119D3_455.a (PCR reagent)
Laboratory	JA
Date	2003-1-10
Reference	Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
JA:Y48B6A.8
Adult Phenotypes	WT
RNAi Reagent Name & Type	sjj_Y48B6A.8 (PCR reagent)
Laboratory	JA
Date	2003-1-10
Reference	Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Gene Plot of Y48B6A.8	*Browse using GBrowse*